EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.4 | warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7- and 10-hydroxylated warfarin | Anas platyrhynchos | |
1.17.4.4 | warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin | Bubo scandiacus | |
1.17.4.4 | warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin | Bubo virginianus | |
1.17.4.4 | warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin | Gallus gallus | |
1.17.4.4 | warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin | Rattus norvegicus | |
1.17.4.4 | warfarin | determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, and 8-hydroxylated warfarin | Struthio camelus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.4.4 | 0.1658 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 37°C | Gallus gallus | |
1.17.4.4 | 0.1761 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 37°C | Rattus norvegicus | |
1.17.4.4 | 0.1875 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 37°C | Struthio camelus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.4.4 | microsome | - |
Gallus gallus | - |
- |
1.17.4.4 | microsome | - |
Rattus norvegicus | - |
- |
1.17.4.4 | microsome | - |
Anas platyrhynchos | - |
- |
1.17.4.4 | microsome | - |
Struthio camelus | - |
- |
1.17.4.4 | microsome | - |
Bubo scandiacus | - |
- |
1.17.4.4 | microsome | - |
Bubo virginianus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Gallus gallus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Rattus norvegicus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Anas platyrhynchos | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Struthio camelus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Bubo scandiacus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | Bubo virginianus | - |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Gallus gallus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Rattus norvegicus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Anas platyrhynchos | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Struthio camelus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Bubo scandiacus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Bubo virginianus | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.4 | Anas platyrhynchos | - |
- |
- |
1.17.4.4 | Bubo scandiacus | - |
- |
- |
1.17.4.4 | Bubo virginianus | - |
- |
- |
1.17.4.4 | Gallus gallus | - |
- |
- |
1.17.4.4 | Rattus norvegicus | - |
- |
- |
1.17.4.4 | Struthio camelus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.17.4.4 | partially by microsome preparation by ultracentrifugation | Rattus norvegicus |
1.17.4.4 | partially by microsome preparation by ultracentrifugation | Anas platyrhynchos |
1.17.4.4 | partially by microsome preparation by ultracentrifugation | Struthio camelus |
1.17.4.4 | partially by microsome preparation by ultracentrifugation | Bubo scandiacus |
1.17.4.4 | partially by microsome preparation by ultracentrifugation | Bubo virginianus |
1.17.4.4 | partially, microsome preparation by ultracentrifugation | Gallus gallus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.4.4 | liver | - |
Gallus gallus | - |
1.17.4.4 | liver | - |
Rattus norvegicus | - |
1.17.4.4 | liver | - |
Anas platyrhynchos | - |
1.17.4.4 | liver | - |
Struthio camelus | - |
1.17.4.4 | liver | - |
Bubo scandiacus | - |
1.17.4.4 | liver | - |
Bubo virginianus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Gallus gallus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Rattus norvegicus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Anas platyrhynchos | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Struthio camelus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Bubo scandiacus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O | - |
Bubo virginianus | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Gallus gallus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Rattus norvegicus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Anas platyrhynchos | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Struthio camelus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Bubo scandiacus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r | |
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Bubo virginianus | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.4.4 | vitamin K 2,3-epoxide reductase | - |
Gallus gallus |
1.17.4.4 | vitamin K 2,3-epoxide reductase | - |
Rattus norvegicus |
1.17.4.4 | vitamin K 2,3-epoxide reductase | - |
Anas platyrhynchos |
1.17.4.4 | vitamin K 2,3-epoxide reductase | - |
Struthio camelus |
1.17.4.4 | vitamin K 2,3-epoxide reductase | - |
Bubo scandiacus |
1.17.4.4 | vitamin K 2,3-epoxide reductase | - |
Bubo virginianus |
1.17.4.4 | VKOR | - |
Gallus gallus |
1.17.4.4 | VKOR | - |
Rattus norvegicus |
1.17.4.4 | VKOR | - |
Anas platyrhynchos |
1.17.4.4 | VKOR | - |
Struthio camelus |
1.17.4.4 | VKOR | - |
Bubo scandiacus |
1.17.4.4 | VKOR | - |
Bubo virginianus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.4.4 | 37 | - |
- |
Rattus norvegicus |
1.17.4.4 | 37 | - |
- |
Anas platyrhynchos |
1.17.4.4 | 38 | - |
- |
Struthio camelus |
1.17.4.4 | 41 | - |
- |
Bubo scandiacus |
1.17.4.4 | 41 | - |
- |
Bubo virginianus |
1.17.4.4 | 42 | - |
- |
Gallus gallus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.17.4.4 | 7.4 | - |
assay at | Gallus gallus |
1.17.4.4 | 7.4 | - |
assay at | Rattus norvegicus |
1.17.4.4 | 7.4 | - |
assay at | Anas platyrhynchos |
1.17.4.4 | 7.4 | - |
assay at | Struthio camelus |
1.17.4.4 | 7.4 | - |
assay at | Bubo scandiacus |
1.17.4.4 | 7.4 | - |
assay at | Bubo virginianus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.4.4 | 0.00028 | - |
warfarin | pH 7.4, 37°C | Rattus norvegicus | |
1.17.4.4 | 0.00064 | - |
warfarin | pH 7.4, 38°C | Struthio camelus | |
1.17.4.4 | 0.0113 | - |
warfarin | pH 7.4, 42°C | Gallus gallus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.17.4.4 | evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Gallus gallus |
1.17.4.4 | evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Anas platyrhynchos |
1.17.4.4 | evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Struthio camelus |
1.17.4.4 | evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Bubo scandiacus |
1.17.4.4 | evolution | clear difference in VKOR activity and Ki for warfarin among bird species | Bubo virginianus |