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Literature summary extracted from
- Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase (2011), IUBMB Life, 63, 1101-1110.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.9 | 3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | competitive kinetics with cofactor NADH and uncompetitive kinetics with the substrate crotonyl-CoA | Plasmodium falciparum |  |
| 1.3.1.9 | 3-bromo-N-[4-(trifluoromethyl)benzyl]-1-benzothiophene-2-carboxamide | competitive kinetics with cofactor NADH and uncompetitive kinetics with the substrate crotonyl-CoA | Plasmodium falciparum | |
| 1.3.1.9 | triclosan | - |
Plasmodium falciparum | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.9 | Plasmodium falciparum | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.9 | crotonyl-CoA + NADH + H+ | - |
Plasmodium falciparum | butyryl-CoA + NAD+ | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.9 | 0.000018 | - |
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | substrate NADH, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 1.3.1.9 | 0.000091 | - |
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | substrate crotonyl-CoA, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.9 | 0.000089 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | triclosan | |
| 1.3.1.9 | 0.000115 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | |
| 1.3.1.9 | 0.000463 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3-bromo-N-[4-(trifluoromethyl)benzyl]-1-benzothiophene-2-carboxamide | |
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