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Literature summary extracted from

  • Liu, N.; Cummings, J.E.; England, K.; Slayden, R.A.; Tonge, P.J.
    Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei (2011), J. Antimicrob. Chemother., 66, 564-573.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9 expression in Escherichia coli Burkholderia pseudomallei

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 2-phenoxy-5-propylphenol minimal inhibitory concentration for Burkholderia pseudomallei growth above 250 mg/l Burkholderia pseudomallei
1.3.1.9 5-ethyl-2-phenoxyphenol minimal inhibitory concentration for Burkholderia pseudomallei growth 70 mg/l Burkholderia pseudomallei
1.3.1.9 5-pentyl-2-phenoxyphenol minimal inhibitory concentration for Burkholderia pseudomallei growth above 250 mg/l Burkholderia pseudomallei
1.3.1.9 triclosan minimal inhibitory concentration for Burkholderia pseudomallei growth 30 mg/l Burkholderia pseudomallei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.9 0.0017
-
trans-2-dodecenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 0.0056
-
trans-2-decenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 0.027
-
crotonyl-[acyl-carrier-protein] pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 0.16
-
trans-2-octenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 0.188
-
crotonyl-CoA pH 6.8, 25°C Burkholderia pseudomallei

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Burkholderia pseudomallei Q3JQY0
-
-
1.3.1.9 Burkholderia pseudomallei 1710b Q3JQY0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-CoA + NADH + H+
-
Burkholderia pseudomallei butyryl-CoA + NAD+
-
?
1.3.1.9 crotonyl-CoA + NADH + H+
-
Burkholderia pseudomallei 1710b butyryl-CoA + NAD+
-
?
1.3.1.9 crotonyl-[acyl-carrier-protein] + NADH + H+
-
Burkholderia pseudomallei butyryl-[acyl-carrier-protein] + NAD+
-
?
1.3.1.9 crotonyl-[acyl-carrier-protein] + NADH + H+
-
Burkholderia pseudomallei 1710b butyryl-[acyl-carrier-protein] + NAD+
-
?
1.3.1.9 additional information catalyzes the NADH-dependent reduction of 2-trans-dodecenoyl-CoA via a sequential Bi Bi mechanism Burkholderia pseudomallei ?
-
?
1.3.1.9 additional information catalyzes the NADH-dependent reduction of 2-trans-dodecenoyl-CoA via a sequential Bi Bi mechanism Burkholderia pseudomallei 1710b ?
-
?
1.3.1.9 trans-2-decenoyl-CoA + NADH + H+
-
Burkholderia pseudomallei decanoyl-CoA + NAD+
-
?
1.3.1.9 trans-2-decenoyl-CoA + NADH + H+
-
Burkholderia pseudomallei 1710b decanoyl-CoA + NAD+
-
?
1.3.1.9 trans-2-dodecenoyl-CoA + NADH + H+
-
Burkholderia pseudomallei dodecanoyl-CoA + NAD+
-
?
1.3.1.9 trans-2-dodecenoyl-CoA + NADH + H+
-
Burkholderia pseudomallei 1710b dodecanoyl-CoA + NAD+
-
?
1.3.1.9 trans-2-octenoyl-CoA + NADH + H+
-
Burkholderia pseudomallei octanoyl-CoA + NAD+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 FabI-1
-
Burkholderia pseudomallei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.1.9 3.6
-
crotonyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 4
-
crotonyl-[acyl-carrier-protein] pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 5.6
-
trans-2-decenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 8.4
-
trans-2-dodecenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 28.3
-
trans-2-octenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.00000051
-
pH 6.8, 25°C Burkholderia pseudomallei 5-ethyl-2-phenoxyphenol
1.3.1.9 0.0000013
-
pH 6.8, 25°C Burkholderia pseudomallei 2-phenoxy-5-propylphenol
1.3.1.9 0.00000157
-
pH 6.8, 25°C Burkholderia pseudomallei triclosan
1.3.1.9 0.0000018
-
pH 6.8, 25°C Burkholderia pseudomallei 5-pentyl-2-phenoxyphenol

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.3.1.9 20
-
crotonyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 150
-
crotonyl-[acyl-carrier-protein] pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 183
-
trans-2-octenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 1000
-
trans-2-decenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei
1.3.1.9 5000
-
trans-2-dodecenoyl-CoA pH 6.8, 25°C Burkholderia pseudomallei