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Literature summary extracted from

  • Stoffels, L.; Krehenbrink, M.; Berks, B.C.; Unden, G.
    Thiosulfate reduction in Salmonella enterica is driven by the proton motive force (2012), J. Bacteriol., 194, 475-485.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.1.5 expressed in Escherichia coli DH5alpha cells Salmonella enterica

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.1.5 3,3',4',5-tetrachlorosalicylanilide sulfide production is nearly completely inhibited (less than 5% residual activity) when low concentrations of 3,3',4',5-tetrachlorosalicylanilide is added Salmonella enterica
2.8.1.5 carbonyl cyanide-3-chlorophenylhydrazone sulfide production is nearly completely inhibited (less than 5% residual activity) when low concentrations of the protonophore carbonyl cyanide-3-chlorophenylhydrazone is added Salmonella enterica
2.8.1.5 carbonyl cyanide-4-trifluoromethoxyphenylhydrazone sulfide production is nearly completely inhibited (less than 5% residual activity) when low concentrations of carbonyl cyanide-4-trifluoromethoxyphenylhydrazone is added Salmonella enterica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.1.5 membrane
-
 Salmonella enterica 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.5 Salmonella enterica
-
-
-
2.8.1.5 Salmonella enterica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.5 sulfite + hydrogen sulfide + menaquinone
-
 Salmonella enterica thiosulfate + menaquinol thiosulfate reductase is able to catalyze the combined oxidation of sulfide and sulfite to thiosulfate in a reverse of the physiological reaction r
1.8.5.5 thiosulfate + menaquinol
-
 Salmonella enterica sulfite + hydrogen sulfide + menaquinone
-
 r
2.8.1.5 additional information ubiquinone is not an electron donor to thiosulfate reductase Salmonella enterica ?
-
 ?
2.8.1.5 thiosulfate + dithiothreitol
-
 Salmonella enterica sulfite + oxidized dithiothreitol + sulfide
-
 ?
2.8.1.5 thiosulfate + menaquinol
-
 Salmonella enterica sulfite + oxidized menaquinol + sulfide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.5 thiosulfate reductase
-
 Salmonella enterica

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.5.5 menaquinol menaquinol is the sole electron donor to thiosulfate reductase Salmonella enterica

General Information

EC Number General Information Comment Organism
1.8.5.5 physiological function thiosulfate reductase activity depends on the proton motive force across the cytoplasmic membrane. The proton motive force drives endergonic electron flow within the enzyme by a reverse loop mechanism. Thiosulfate reductase is able to catalyze the combined oxidation of sulfide and sulfite to thiosulfate in a reverse of the physiological reaction. In contrast to the forward reaction, the exergonic thiosulfate-forming reaction is independent of the proton motive force Salmonella enterica