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Literature summary extracted from

  • Marsh, V.L.; Peak-Chew, S.Y., Bell, S.D.
    Sir2 and the acetyltransferase, Pat, regulate the archaeal chromatin protein, Alba (2005), J. Biol. Chem., 280, 21122-21128.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B27 expressed in Escherichia coli as a C-terminally hexahistidine-tagged protein Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B27 acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 Saccharolobus solfataricus the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?
2.3.1.B27 acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 Saccharolobus solfataricus P2 the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B27 Saccharolobus solfataricus Q97V23
-
-
2.3.1.B27 Saccharolobus solfataricus P2 Q97V23
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.B27
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B27 acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation Saccharolobus solfataricus CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?
2.3.1.B27 acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the enzyme specifically acetylates protein Alba1 (SSO0962) on L-lysine 16 Saccharolobus solfataricus CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?
2.3.1.B27 acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation Saccharolobus solfataricus P2 CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?
2.3.1.B27 acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the enzyme specifically acetylates protein Alba1 (SSO0962) on L-lysine 16 Saccharolobus solfataricus P2 CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B27 SSO2813 locus name Saccharolobus solfataricus
2.3.1.B27 ssPat
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.B27 65
-
 assay at Saccharolobus solfataricus
2.3.1.B27 70 90
-
 Saccharolobus solfataricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.B27 8
-
 assay at Saccharolobus solfataricus

General Information

EC Number General Information Comment Organism
2.3.1.B27 physiological function the DNA binding affinity of the chromatin protein Alba1 is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA Saccharolobus solfataricus