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Literature summary extracted from

  • Faraone-Mennella, M.R.; Piccialli, G.; De Luca, P.; Castellano, S.; Giordano, A.; Rigano, D.; De Napoli, L.; Farina, B.
    Interaction of the ADP-ribosylating enzyme from the hyperthermophilic archaeon Sulfolobus solfataricus with DNA and ss-oligo deoxy ribonucleotides (2002), J. Cell. Biochem., 85, 146-157.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.30 DNA slightly increases activity Saccharolobus solfataricus
2.4.2.30 oligodeoxyribonucleotides slightly enhance enzyme activity with the maximal increase of 50% as compared to the control Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Saccharolobus solfataricus the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Saccharolobus solfataricus MT-4 / DSM 5833 the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Saccharolobus solfataricus B3EWG9
-
-
2.4.2.30 Saccharolobus solfataricus MT-4 / DSM 5833 B3EWG9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.30
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Saccharolobus solfataricus nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA Saccharolobus solfataricus nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Saccharolobus solfataricus MT-4 / DSM 5833 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA Saccharolobus solfataricus MT-4 / DSM 5833 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.30 80
-
 assay at Saccharolobus solfataricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.30 8
-
 assay at Saccharolobus solfataricus