Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Verner, Z.; Skodova, I.; Polakova, S.; Durisova-Benkovicova, V.; Horvath, A.; Lukes, J.
    Alternative NADH dehydrogenase (NDH2): intermembrane-space-facing counterpart of mitochondrial complex I in the procyclic Trypanosoma brucei (2013), Parasitology, 140, 328-337.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.6.5.9 additional information NDH2 gene silencing using tetracycline-inducible RNAi Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.9 NADH + H+ + ubiquinone Trypanosoma brucei
-
 NAD+ + ubiquinol
-
 ?
1.6.5.9 NADH + H+ + ubiquinone Trypanosoma brucei 29-13
-
 NAD+ + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.9 Trypanosoma brucei
-
-
-
1.6.5.9 Trypanosoma brucei 29-13
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.9 NADH + H+ + ubiquinone
-
 Trypanosoma brucei NAD+ + ubiquinol
-
 ?
1.6.5.9 NADH + H+ + ubiquinone
-
 Trypanosoma brucei 29-13 NAD+ + ubiquinol
-
 ?

Subunits

EC Number Subunits Comment Organism
1.6.5.9 monomer
-
 Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
1.6.5.9 alternative NADH dehydrogenase
-
 Trypanosoma brucei
1.6.5.9 alternative rotenone-insensitive NADH:Q oxidoreductase
-
 Trypanosoma brucei
1.6.5.9 NADH: ubiquinone-2 oxidoreductase
-
 Trypanosoma brucei
1.6.5.9 NADHQ2
-
 Trypanosoma brucei
1.6.5.9 NDH2
-
 Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.9 NADH
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
1.6.5.9 malfunction the induced RNAi cell line exhibits slower growth, decreased mitochondrial membrane potential and lower sensitivity of respiration to inhibitors. Mitochondrial membrane potential is altered in NDH2 knockdown. Growth phenotype of procyclic Trypanosoma brucei interfered against NDH2, overview Trypanosoma brucei
1.6.5.9 physiological function NDH2 is a part of the respiratory chain that does not pump protons across the inner membrane. NDH2 is the major NADH: ubiquinone oxidoreductase responsible for cytosolic and not for mitochondrial NAD+ regeneration in the mitochondrion of procyclic Trypanosoma brucei. thatNDH2is facing intermembrane space, rendering complex I responsible only for the regeneration of matrix NAD+. Ability of NDH2 to fully compensate for the loss of complex I. NDH2 is essential for the maintenance of mitochondrial membrane potential in procyclic Trypanosoma brucei Trypanosoma brucei