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Literature summary extracted from
- Eubacteria-type isocitrate dehydrogenase from an archaeon: cloning, sequencing, and expression of a gene encoding isocitrate dehydrogenase from a hyperthermophilic archaebacterium, Caldococcus noboribetus (1996), Arch. Biochem. Biophys., 336, 77-85.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.42 | expression of the gene in Escherichia coli by connecting it with the T7 promoter | Caldococcus noboribetus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 48000 | - |
x * 48000, SDS-PAGE | Caldococcus noboribetus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.42 | isocitrate + NADP+ | Caldococcus noboribetus | strict substrate and coenzyme specificity | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.42 | Caldococcus noboribetus | P96318 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.42 | isocitrate + NADP+ | strict substrate and coenzyme specificity | Caldococcus noboribetus | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.42 | ? | x * 48000, SDS-PAGE | Caldococcus noboribetus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.42 | ICDH | - |
Caldococcus noboribetus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 80 | - |
assay at | Caldococcus noboribetus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 70 | 80 | stable | Caldococcus noboribetus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.42 | 7 | - |
assay at | Caldococcus noboribetus |
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Release 2023.1 (January 2023)
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