BRENDA - Enzyme Database

Novel inositol catabolic pathway in Thermotoga maritima

Rodionova, I.A.; Leyn, S.A.; Burkart, M.D.; Boucher, N.; Noll, K.M.; Osterman, A.L.; Rodionov, D.A.; Environ. Microbiol. 15, 2254-2266 (2013)

Data extracted from this reference:

KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.369
2.9
-
1D-chiro-inositol
pH 8.8, 60°C
Thermotoga maritima
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.369
Thermotoga maritima
Q9WYP5
-
-
1.1.1.369
Thermotoga maritima DSM 3109
Q9WYP5
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.369
1D-chiro-inositol + NAD+
-
727372
Thermotoga maritima
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
-
-
-
?
1.1.1.369
1D-chiro-inositol + NAD+
-
727372
Thermotoga maritima DSM 3109
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
-
-
-
?
1.1.1.369
additional information
The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
727372
Thermotoga maritima
?
-
-
-
-
1.1.1.369
additional information
The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
727372
Thermotoga maritima DSM 3109
?
-
-
-
-
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.1.1.369
1
-
1D-chiro-inositol
pH 8.8, 60°C
Thermotoga maritima
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.369
2.9
-
1D-chiro-inositol
pH 8.8, 60°C
Thermotoga maritima
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.369
1D-chiro-inositol + NAD+
-
727372
Thermotoga maritima
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
-
-
-
?
1.1.1.369
1D-chiro-inositol + NAD+
-
727372
Thermotoga maritima DSM 3109
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
-
-
-
?
1.1.1.369
additional information
The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
727372
Thermotoga maritima
?
-
-
-
-
1.1.1.369
additional information
The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
727372
Thermotoga maritima DSM 3109
?
-
-
-
-
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.1.1.369
1
-
1D-chiro-inositol
pH 8.8, 60°C
Thermotoga maritima
KCat/KM [mM/s]
EC Number
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.1.1.369
345
-
1D-chiro-inositol
pH 8.8, 60°C
Thermotoga maritima
KCat/KM [mM/s] (protein specific)
EC Number
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.1.1.369
345
-
1D-chiro-inositol
pH 8.8, 60°C
Thermotoga maritima