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Literature summary extracted from

  • Pulaganti, M.; Banaganapalli, B.; Mulakayala, C.; Chitta, S.K.; C M, A.
    Molecular modeling and docking studies of O-succinylbenzoate synthase of M. tuberculosis - a potential target for antituberculosis drug design (2014), Appl. Biochem. Biotechnol., 172, 1407-1432.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.113 drug development the enzyme plays a major role in menaquinone biosynthesis and is one of the major potential drug targets for development of antibiotics Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.113 gene menC, phylogenetic analysis Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.113 additional information docking of potential inhibitors, inhibitor development via competitive binding of the substrate, overview. Design of a substrate-based analogue, evaluation of auxiliary molecule interaction energies through molecular docking and molecular dynamic simulation studies Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis
-
 2-succinylbenzoate + H2O
-
 ?
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis H37Rv
-
 2-succinylbenzoate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.113 Mycobacterium tuberculosis
-
 gene menC
-
4.2.1.113 Mycobacterium tuberculosis H37Rv
-
 gene menC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis 2-succinylbenzoate + H2O
-
 ?
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis H37Rv 2-succinylbenzoate + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.113 More three-dimensional structure modeling taking crystal structure of the enzyme from Thermobifida fusca YX (PDB ID 2OPJ) as the template, overview Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
4.2.1.113 OSBS
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
4.2.1.113 metabolism the enzyme is important in the menaquinone biosynthesis Mycobacterium tuberculosis
4.2.1.113 additional information Lys108, Asn140, Asp138, Lys110, Glu189, Ser236, Asp188, Arg27, Tyr52, and Ser237 are highly conserved and may play a vital role as active residues Mycobacterium tuberculosis