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Literature summary extracted from

  • Kratky, D.; Obrowsky, S.; Kolb, D.; Radovic, B.
    Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis (2014), Biochimie, 96, 106-112.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.3 CGI-58 for maximal lipolytic activity the enzyme requires CGI-58 as a co-activator Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.3 adipocyte
-
 Mus musculus
-
3.1.1.3 brain
-
 Mus musculus
-
3.1.1.3 brown adipose tissue
-
 Mus musculus
-
3.1.1.3 cardiac muscle
-
 Mus musculus
-
3.1.1.3 INS-1 823/13 cell
-
 Mus musculus
-
3.1.1.3 liver
-
 Mus musculus
-
3.1.1.3 macrophage
-
 Mus musculus
-
3.1.1.3 skeletal muscle
-
 Mus musculus
-
3.1.1.3 small intestine
-
 Mus musculus
-
3.1.1.3 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 additional information the enzyme lacks the ability to hydrolyze diacylglycerols, monoacylglycerols, cholesteryl esters, or retinyl esters Mus musculus ?
-
 ?
3.1.1.3 triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 adipose triglyceride lipase
-
 Mus musculus
3.1.1.3 ATGL
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.3 malfunction the absence of adipose triglyceride lipase has pleiotropic roles in mitochondrial function Mus musculus