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Literature summary extracted from

  • Powell, P.K.; Wolf, I.; Jin, R.; Lasker, J.M.
    Metabolism of arachidonic acid to 20-hydroxy-5,8,11,14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11 (1998), J. Pharmacol. Exp. Ther., 285, 1327-1336.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.78 0.0235
-
 arachidonic acid pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.78 phylloquinone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.78 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.78 kidney
-
 Homo sapiens
-
1.14.14.78 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.78 arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens (5Z,8Z,11Z,14Z)-20-hydroxyeicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.78 phylloquinone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.78 CYP4F2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.78 NADPH
-
 Homo sapiens