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Literature summary extracted from

  • Farley, S.M.; Leonard, S.W.; Taylor, A.W.; Birringer, M.; Edson, K.Z.; Rettie, A.E.; Traber, M.G.
    omega-Hydroxylation of phylloquinone by CYP4F2 is not increased by alpha-tocopherol (2013), Mol. Nutr. Food Res., 57, 1785-1793.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.78 additional information Rattus norvegicus CYP4F2 discriminates between tocopherols and phylloquinone in vitro, but alpha-tocopherol does not apparently increase phylloquinone omega-hydroxylation by this mechanism ?
-
 ?
1.14.14.78 phylloquinone + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.78 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.78 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.78 gamma-tocopherol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 13'-hydroxy-gamma-tocopherol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.78 additional information CYP4F2 discriminates between tocopherols and phylloquinone in vitro, but alpha-tocopherol does not apparently increase phylloquinone omega-hydroxylation by this mechanism Rattus norvegicus ?
-
 ?
1.14.14.78 phylloquinone + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.78 CYP4F2
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.78 NADPH
-
 Rattus norvegicus