EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.244 | 277000 | - |
- |
Aspergillus terreus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.244 | acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine | Aspergillus terreus | the enzyme is involved in the lovastatin biosynthetic pathway | (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.244 | Aspergillus terreus | Q9Y7D5 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.244 | acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine | the enzyme is involved in the lovastatin biosynthetic pathway | Aspergillus terreus | (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O | - |
? | |
2.3.1.244 | acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine | the overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta enoyl reduction | Aspergillus terreus | (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.244 | ? | 277000, calculated from sequence | Aspergillus terreus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.244 | LocF | - |
Aspergillus terreus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.244 | 4'-phosphopantetheine | covalently bound | Aspergillus terreus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.244 | metabolism | the enzyme is involved in the lovastatin biosynthetic pathway | Aspergillus terreus |