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Literature summary extracted from
- Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases (2005), Mol. Microbiol., 57, 276-290.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.11.48 | - |
Aspergillus nidulans |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.48 | EDTA | - |
Aspergillus nidulans |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.48 | additional information | - |
xanthine | KM-value determined in crude extract: 0.023 mM | Aspergillus nidulans | |
| 1.14.11.48 | additional information | - |
2-oxoglutarate | KM-value determined in crude extract: 0.05 mM | Aspergillus nidulans | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.48 | Fe2+ | Fe2+-dependent enzyme | Aspergillus nidulans | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.48 | xanthine + 2-oxoglutarate + O2 | Aspergillus nidulans | - |
urate + succinate + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.48 | Aspergillus nidulans | Q4QZZ9 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.48 | xanthine + 2-oxoglutarate + O2 | - |
Aspergillus nidulans | urate + succinate + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.11.48 | alpha-ketoglutarate-dependent xanthine hydroxylase | - |
Aspergillus nidulans |
| 1.14.11.48 | XanA | - |
Aspergillus nidulans |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.48 | 30 | - |
assay at | Aspergillus nidulans |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.48 | 6.9 | - |
assay at | Aspergillus nidulans |
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Release 2023.1 (January 2023)
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