EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.15.1 | crystal structure of human C-domain sACE in complex with two natural peptides, angiotensin II, and with a snake venom inhibitor-bradykinin potentiating peptide (BPPb, a human C-domain specific peptide inhibitor) is shown. The structure of the complex with BPPb reveals molecular interactions in a zinc independent manner. The structure of the C-domain sACE-angiotensin II complex reveals the role of the penultimate Pro residue of angiotensin II in conferring resistance to hydrolysis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.15.1 | angiotensin II | angiotensin II shows selective competitive inhibition of the carboxy-terminal domain of human somatic ACE | Homo sapiens | |
3.4.15.1 | bradykinin potentiating peptide b | interaction with sACE in a Zn-dependent manner | Homo sapiens | |
3.4.15.1 | captopril | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.15.1 | Homo sapiens | P12821 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | hippuryl-L-His-L-Leu + H2O | - |
Homo sapiens | hippuric acid + L-His-L-Leu | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.15.1 | sACE | - |
Homo sapiens |
3.4.15.1 | somatic ACE | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.15.1 | 0.004 | - |
angiotensin II | C-terminal domain of sACE, pH 7.5, temperature not specified in the publication | Homo sapiens | |
3.4.15.1 | 0.076 | - |
angiotensin II | N-terminal domain of sACE, pH 7.5, temperature not specified in the publication | Homo sapiens |