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Literature summary extracted from
- Cloning, expression, and fatty acid regulation of the human DELTA-5 desaturase (1999), J. Biol. Chem., 274, 37335-37339.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.19.30 | expressed in CHO cells | Rattus norvegicus |
| 1.14.19.30 | expressed in CHO cells | Homo sapiens |
| 1.14.19.44 | expressed in Chinese hamster ovary cells | Homo sapiens |
| 1.14.19.44 | expressed in Chinese hamster ovary cells | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.19.30 | membrane | - |
Rattus norvegicus | 16020 | - |
| 1.14.19.30 | membrane | - |
Homo sapiens | 16020 | - |
| 1.14.19.44 | membrane | - |
Homo sapiens | 16020 | - |
| 1.14.19.44 | membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? |  |
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.30 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.30 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
arachidonoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
arachidonoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.30 | Homo sapiens | Q9Y5Q0 | - |
- |
| 1.14.19.30 | Rattus norvegicus | - |
- |
- |
| 1.14.19.44 | Homo sapiens | - |
- |
- |
| 1.14.19.44 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.30 | brain | most abundant | Homo sapiens | - |
| 1.14.19.30 | heart | most abundant | Homo sapiens | - |
| 1.14.19.30 | kidney | - |
Homo sapiens | - |
| 1.14.19.30 | liver | most abundant | Homo sapiens | - |
| 1.14.19.30 | lung | - |
Homo sapiens | - |
| 1.14.19.30 | pancreas | - |
Homo sapiens | - |
| 1.14.19.30 | placenta | - |
Homo sapiens | - |
| 1.14.19.30 | skeletal muscle | - |
Homo sapiens | - |
| 1.14.19.44 | brain | most abundant in the brain | Homo sapiens | - |
| 1.14.19.44 | heart | most abundant in the heart | Homo sapiens | - |
| 1.14.19.44 | kidney | - |
Homo sapiens | - |
| 1.14.19.44 | liver | most abundant in the liver | Homo sapiens | - |
| 1.14.19.44 | lung | - |
Homo sapiens | - |
| 1.14.19.44 | pancreas | - |
Homo sapiens | - |
| 1.14.19.44 | placenta | - |
Homo sapiens | - |
| 1.14.19.44 | skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.30 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.30 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.30 | additional information | no activity with 18:3(n-3) | Rattus norvegicus | ? | - |
? | |
| 1.14.19.30 | additional information | no activity with 18:3(n-3) | Homo sapiens | ? | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | arachidonoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | arachidonoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.44 | (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.30 | D5D | - |
Rattus norvegicus |
| 1.14.19.30 | D5D | - |
Homo sapiens |
| 1.14.19.30 | delta-5 desaturase | - |
Rattus norvegicus |
| 1.14.19.30 | delta-5 desaturase | - |
Homo sapiens |
| 1.14.19.44 | D5D | - |
Homo sapiens |
| 1.14.19.44 | D5D | - |
Rattus norvegicus |
| 1.14.19.44 | delta-5 desaturase | - |
Homo sapiens |
| 1.14.19.44 | delta-5 desaturase | - |
Rattus norvegicus |
| 1.14.19.44 | FADS1 | - |
Homo sapiens |
| 1.14.19.44 | FADS1 | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.30 | cytochrome b5 | - |
Rattus norvegicus | |
| 1.14.19.30 | cytochrome b5 | - |
Homo sapiens | |
| 1.14.19.44 | cytochrome b5 | - |
Homo sapiens | |
| 1.14.19.44 | cytochrome b5 | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.19.30 | Rattus norvegicus | when rats are fed a diet containing 10% (v/v) safflower oil or menhaden fish oil, the level of hepatic mRNA is 25% of that found in the liver of rats fed a fat-free diet or a diet containing triolein | down |
| 1.14.19.44 | Rattus norvegicus | when rats are fed a diet containing 10% safflower oil or menhaden fish oil, the level of hepatic mRNA for DELTA-5 desaturase is 25% of that found in the liver of rats fed a fat-free diet or a diet containing triolein | down |
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