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Literature summary extracted from

  • Ternes, P.; Wobbe, T.; Schwarz, M.; Albrecht, S.; Feussner, K.; Riezman, I.; Cregg, J.; Heinz, E.; Riezman, H.; Feussner, I.; Warnecke, D.
    Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris (2011), J. Biol. Chem., 286, 11401-11414.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Komagataella pastoris
-
 (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.17 Komagataella pastoris
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
 Komagataella pastoris (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.17 sphingolipid DELTA4-desaturase
-
 Komagataella pastoris

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.17 cytochrome b5
-
 Komagataella pastoris

General Information

EC Number General Information Comment Organism
1.14.19.17 metabolism DELTA4-desaturation is essential for conversion of the ceramide pool with dihydroxy long-chain sphingoid base and C16/C18 fatty acids into glyosylceramide Komagataella pastoris