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Literature summary extracted from

  • Park, W.J.; Kothapalli, K.S.; Reardon, H.T.; Lawrence, P.; Qian, S.B.; Brenna, J.T.
    A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids (2012), J. Lipid Res., 53, 1502-1512.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.44 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.14.19.44 endoplasmic reticulum
-
 Papio anubis 5783
-
1.14.19.44 mitochondrion
-
 Homo sapiens 5739
-
1.14.19.44 mitochondrion
-
 Papio anubis 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.44 54000
-
 x * 54000, SDS-PAGE Homo sapiens
1.14.19.44 54000
-
 x * 54000, SDS-PAGE Papio anubis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.44 (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ Papio anubis
-
 arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ Papio anubis
-
 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.44 Homo sapiens
-
-
-
1.14.19.44 Papio anubis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.44 brain
-
 Papio anubis
-
1.14.19.44 Hep-G2 cell
-
 Homo sapiens
-
1.14.19.44 liver
-
 Papio anubis
-
1.14.19.44 MCF-7 cell
-
 Homo sapiens
-
1.14.19.44 neuronal cell
-
 Homo sapiens
-
1.14.19.44 SK-N-SH cell
-
 Homo sapiens
-
1.14.19.44 thymus
-
 Papio anubis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.44 (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Papio anubis arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Papio anubis (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
-
 Papio anubis arachidonic acid + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 dihomo-gamma-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 eicosatetraenoic acid + ferrocytochrome b5 + O2 + H+
-
 Papio anubis eicosapentaenoic acid + ferricytochrome b5 + H2O
-
 ?
1.14.19.44 eicosatetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens eicosapentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.44 ? x * 54000, SDS-PAGE Homo sapiens
1.14.19.44 ? x * 54000, SDS-PAGE Papio anubis

Synonyms

EC Number Synonyms Comment Organism
1.14.19.44 acyl-CoA 5-desaturase
-
 Homo sapiens
1.14.19.44 acyl-CoA 5-desaturase
-
 Papio anubis
1.14.19.44 FADS1
-
 Homo sapiens
1.14.19.44 FADS1
-
 Papio anubis

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.44 cytochrome b5
-
 Homo sapiens
1.14.19.44 cytochrome b5
-
 Papio anubis

General Information

EC Number General Information Comment Organism
1.14.19.44 metabolism isoform FADS1 alternative transcript 1 enhances desaturation of isoform FADS2 , leading to increased production of eicosanoid precursors Homo sapiens
1.14.19.44 metabolism isoform FADS1 alternative transcript 1 enhances desaturation of isoform FADS2 , leading to increased production of eicosanoid precursors Papio anubis