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Literature summary extracted from

  • Wilcoxen, J.; Zhang, B.; Hille, R.
    Reaction of the molybdenum- and copper-containing carbon monoxide dehydrogenase from Oligotropha carboxydovorans with quinones (2011), Biochemistry, 50, 1910-1916.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.5.3 CO + a quinone + H2O
-
-
CO2 + a quinol
-
?
1.2.5.3 CO + a quinone + H2O Afipia carboxidovorans ATCC 49405
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CO2 + a quinol
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?

Organism

EC Number Organism UniProt Comment Textmining
1.2.5.3 Afipia carboxidovorans ATCC 49405 P19919 AND P19920 AND P19921 genes coxL, coxM, and coxS; genes coxS, coxM, and coxL
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.5.3 CO + 1,2-naphthoquinone-4-sulfonic acid + H2O
-
-
CO2 + 1,2-naphthoquinol-4-sulfonic acid
-
?
1.2.5.3 CO + 1,2-naphthoquinone-4-sulfonic acid + H2O
-
Afipia carboxidovorans ATCC 49405 CO2 + 1,2-naphthoquinol-4-sulfonic acid
-
?
1.2.5.3 CO + 1,4-naphthoquinone + H2O
-
-
CO2 + 1,4-naphthoquinol
-
?
1.2.5.3 CO + 1,4-naphthoquinone + H2O
-
Afipia carboxidovorans ATCC 49405 CO2 + 1,4-naphthoquinol
-
?
1.2.5.3 CO + a quinone + H2O
-
-
CO2 + a quinol
-
?
1.2.5.3 CO + a quinone + H2O
-
Afipia carboxidovorans ATCC 49405 CO2 + a quinol
-
?
1.2.5.3 CO + benzoquinone + H2O
-
-
CO2 + benzoquinol
-
?
1.2.5.3 CO + benzoquinone + H2O
-
Afipia carboxidovorans ATCC 49405 CO2 + benzoquinol
-
?
1.2.5.3 CO + ubiquinone-1 + H2O
-
-
CO2 + ubiquinol-1
-
?
1.2.5.3 additional information routine activity is determined by the CO-dependent reduction of methylene blue. No activity with cytochrome b561. Quinone substrates interacted with CODH at its FAD site
-
?
-
?
1.2.5.3 additional information routine activity is determined by the CO-dependent reduction of methylene blue. No activity with cytochrome b561. Quinone substrates interacted with CODH at its FAD site Afipia carboxidovorans ATCC 49405 ?
-
?

Subunits

EC Number Subunits Comment Organism
1.2.5.3 heterohexamer the functional enzyme is a (alphabetagamma)2 hexamer that consists of a small 17.8 kDa subunit (CoxS) containing two [2Fe-2S] clusters, a medium 30.2 kDa subunit (CoxM) containing an FAD cofactor, and a large 88.7 kDa subunit (CoxL) that possesses the molybdenum center
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Synonyms

EC Number Synonyms Comment Organism
1.2.5.3 Carbon monoxide dehydrogenase
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-
1.2.5.3 CODH
-
-
1.2.5.3 molybdenum- and copper-containing carbon monoxide dehydrogenase
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-

General Information

EC Number General Information Comment Organism
1.2.5.3 evolution the enzyme belongs to the XOR family
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1.2.5.3 physiological function carbon monoxide dehydrogenase from Oligotropha carboxydovorans catalyzes the oxidation of carbon monoxide to carbon dioxide, providing the organism both a carbon source and energy for growth. In the oxidative half of the catalytic cycle, electrons gained from CO are ultimately passed to the electron transport chain of the Gram-negative organism. Quinones are catalytically competent as proximal acceptor of reducing equivalents from the enzyme
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