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Literature summary extracted from

  • Scheckhuber, C.Q.; Veenhuis, M.; van der Klei, I.J.
    Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction (2013), Metab. Eng., 18, 36-43.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.164 synthesis strategy to improve penicillin biosynthesis by Penicillium chrysogenum by reducing reactive and toxic metabolic byproducts, 2-oxoaldehydes. This is achieved by overexpressing the genes encoding glyoxalase I and II, which results in a 10% increase in penicillin titers relative to the control strain. The protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased in the glyoxalase transformants, whereas their transcript levels remains unaltered Penicillium chrysogenum

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.164 Penicillium chrysogenum
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2.3.1.164 Penicillium chrysogenum DS17690
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Expression

EC Number Organism Comment Expression
2.3.1.164 Penicillium chrysogenum in strains overexpressing the genes encoding glyoxalase I and II, the protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased up