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Literature summary extracted from

  • Laurieri, N.; Egleton, J.E.; Varney, A.; Thinnes, C.C.; Quevedo, C.E.; Seden, P.T.; Thompson, S.; Rodrigues-Lima, F.; Dairou, J.; Dupret, J.M.; Russell, A.J.; Sim, E.
    A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1 (2013), PLoS ONE, 8, e70600.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expressed in Escherichia coli Rosetta(DE3)pLysS cells Mus musculus
2.3.1.5 expressed in Escherichia coli Rosetta(DE3)pLysS cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide 93.3% inhibition of isoform NAT1 at 0.03 mM and 10.6% inhibition of isoform NAT2 Homo sapiens
2.3.1.5 N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide 37.6% inhibition of isoform Nat1 at 0.03 mM and 92.4% inhibition of isoform Nat2 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.5 acetyl-CoA + an arylamine Mus musculus
-
 CoA + an N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine Homo sapiens
-
 CoA + an N-acetylarylamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens
-
-
-
2.3.1.5 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.5 Ni-NTA column chromatography Mus musculus
2.3.1.5 Ni-NTA column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + an arylamine
-
 Mus musculus CoA + an N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine
-
 Homo sapiens CoA + an N-acetylarylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 NAT1 isoform Mus musculus
2.3.1.5 NAT1 isoform Homo sapiens
2.3.1.5 NAT2 isoform Mus musculus
2.3.1.5 NAT2 isoform Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.5 0.0019
-
 isoform Nat2, pH and temperature not specified in the publication Mus musculus N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide
2.3.1.5 0.0053
-
 isoform NAT1, pH and temperature not specified in the publication Homo sapiens N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide