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Literature summary extracted from

  • Chang, C.; Krishnan, T.; Wang, H.; Chen, Y.; Yin, W.; Chong, Y.; Tan, L.; Chong, T.; Chan, K.
    Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target (2014), Sci. Rep., 4, 7245.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.184 expression in Escherichia coli Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.184 salicylic acid
-
 Pseudomonas aeruginosa
2.3.1.184 Tannic acid efficiently inhibits N-acylhomoserine lactone production by isoform RhlI, specifically target short-chain N-acylhomoserine lactone synthase RhlI Pseudomonas aeruginosa
2.3.1.184 trans-cinnamaldehyde efficiently inhibits N-acylhomoserine lactone production by isoform RhlI, specifically target short-chain N-acylhomoserine lactone synthase RhlI. trans-Cinnamaldehyde reduces the quorum-sensing-regulated pyocyanin production up to 42%; molecular docking ananlysis, mainly interacts with substrate binding sites. trans-Cinnamaldehyde is locked deeply into the binding site and forms hydrophobic and Pi-Pi interactions with surrounding residues Phe27, Trp33 and Phe105 and one hydrogen bond with Arg30 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.184 Pseudomonas aeruginosa P33883
-
-
2.3.1.184 Pseudomonas aeruginosa P54291
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.184 LasI
-
 Pseudomonas aeruginosa
2.3.1.184 RhlI
-
 Pseudomonas aeruginosa