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Literature summary extracted from

  • Cong, W.; Ma, W.; Zhao, T.; Zhu, Z.; Wang, Y.; Tan, Y.; Li, X.; Jin, L.; Cai, L.
    Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374) (2013), Am. J. Physiol. Endocrinol. Metab., 304, E826-E835.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.5 mitochondrion
-
 Mus musculus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.3.5 58000
-
 x * 58000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Mus musculus Q9D0K2
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.8.3.5 nitrosylation diabetes is associated with a higher nitrosylation degree of tyrosine 76 and tyrosine374 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 heart
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate
-
 Mus musculus succinate + acetoacetyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.3.5 ? x * 58000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.8.3.5 SCOT
-
 Mus musculus
2.8.3.5 succinyl-CoA:3-ketoacid coenzyme A transferase-1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.8.3.5 Mus musculus the enzyme catalytic activity is significantly reduced in the hearts of diabetic wild type diabetic mice at weeks 4-12 postinduction, with the lowest level observed at week 4 postinduction down