Literature summary extracted from

Kim, G.H.; Lee, Y.E.; Lee, G.H.; Cho, Y.H.; Lee, Y.N.; Jang, Y.; Paik, D.; Park, J.J.
Overexpression of malic enzyme in the larval stage extends Drosophila lifespan (2015), Biochem. Biophys. Res. Commun., 456, 676-682.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.40	cytoplasm	-	Drosophila melanogaster	5737	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.40	(S)-malate + NADP+	Drosophila melanogaster	-	pyruvate + CO2 + NADPH	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.40	Drosophila melanogaster	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.40	larva	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.40	(S)-malate + NADP+	-	Drosophila melanogaster	pyruvate + CO2 + NADPH	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.40	NADP+	-	Drosophila melanogaster

General Information

EC Number	General Information	Comment	Organism
1.1.1.40	physiological function	malic enzyme overexpression during the larval period lengthenes the lifespan of Drosophila melanogaster. Metabolic changes mediated by the enzyme during development are related to the control of reactive oxygen species tolerance and the longevity of Drosophila	Drosophila melanogaster

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Release 2023.1 (January 2023)