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Literature summary extracted from

  • Weyda, I.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.
    Point mutation of the xylose reductase (XR) gene reduces xylitol accumulation and increases citric acid production in Aspergillus carbonarius (2014), J. Ind. Microbiol. Biotechnol., 41, 733-739.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.430 synthesis in fermentation for citric acid production and xylitol accumulation by using D-xylose as the sole carbon source, a sttrain carrying mutant K274R shows a 2.8fold reduction in xylitol accumulation and 4.5fold increase in citric acid production compared to the wild-type strain Aspergillus carbonarius
1.1.1.431 synthesis in fermentation for citric acid production and xylitol accumulation by using D-xylose as the sole carbon source, a sttrain carrying mutant K274R shows a 2.8fold reduction in xylitol accumulation and 4.5fold increase in citric acid production compared to the wild-type strain Aspergillus carbonarius

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.430 K274R mutation introduced to change the specificity toward NADH. Fermentation with the mutant strain shows a 2.8fold reduction in xylitol accumulation and 4.5fold increase in citric acid production compared to the wild-type strain Aspergillus carbonarius
1.1.1.431 K274R mutation introduced to change the specificity toward NADH. Fermentation with the mutant strain shows a 2.8fold reduction in xylitol accumulation and 4.5fold increase in citric acid production compared to the wild-type strain Aspergillus carbonarius

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.9 xylitol + NAD+ Aspergillus carbonarius
-
 D-xylulose + NADH + H+
-
 ?
1.1.1.9 xylitol + NAD+ Aspergillus carbonarius ITEM 5010
-
 D-xylulose + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.9 Aspergillus carbonarius
-
-
-
1.1.1.430 Aspergillus carbonarius
-
-
-
1.1.1.430 Aspergillus carbonarius ITEM 5010
-
-
-
1.1.1.431 Aspergillus carbonarius
-
-
-
1.1.1.431 Aspergillus carbonarius ITEM 5010
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.9 xylitol + NAD+
-
 Aspergillus carbonarius D-xylulose + NADH + H+
-
 ?
1.1.1.9 xylitol + NAD+
-
 Aspergillus carbonarius ITEM 5010 D-xylulose + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.9 XDH
-
 Aspergillus carbonarius

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.9 NAD+
-
 Aspergillus carbonarius