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Literature summary extracted from

  • Delgado, R.; Munoz, Y.; Pena-Cortes, H.; Giavalisco, P.; Bacigalupo, J.
    Diacylglycerol activates the light-dependent channel TRP in the photosensitive microvilli of Drosophila melanogaster photoreceptors (2014), J. Neurosci., 34, 6679-6686.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.107 gene rdgA Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.107 additional information generation of a mutant defective in the gene encoding DGK, rdgA Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.107 R59022 a specific pharmacological enzyme inhibitor Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 membrane rhabdomeral membrane, the enzyme is located predominantly in the cytoplasmic subrhabdomeral cisternae, a cytoplasmic membrane system located at close distance from the microvilli. Excised membrane patches retain a functional enzyme DGK Drosophila melanogaster 16020
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2.7.1.107 rhabdomere rhabdomeral membrane, the enzyme is located predominantly in the cytoplasmic subrhabdomeral cisternae, a cytoplasmic membrane system located at close distance from the microvilli. Excised membrane patches retain a functional enzyme DGK Drosophila melanogaster 16028
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Drosophila melanogaster
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ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Drosophila melanogaster Oregon-R
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ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Drosophila melanogaster Q09103 gene rdgA
-
2.7.1.107 Drosophila melanogaster Oregon-R Q09103 gene rdgA
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 eye
-
Drosophila melanogaster
-
2.7.1.107 photoreceptor
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
Drosophila melanogaster ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
Drosophila melanogaster Oregon-R ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DAG-kinase
-
Drosophila melanogaster
2.7.1.107 DGK
-
Drosophila melanogaster
2.7.1.107 eye-specific diacylglycerol kinase UniProt Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function light-dependent channel TRP in the light-sensitive microvilli of the photoreceptor's rhabdomere is opened by diacylglycerol and silenced by ATP, suggesting diacylglycerol kinase involvement. The ATP effect is abolished by inhibiting enzyme diacylglycerol kinase DGK and in the rdgA mutant, lacking functional DGK. Diacylglycerol activates TRP even in the presence of a DAG-lipase inhibitor, inconsistent with a requirement of polyunsaturated fatty acids in opening TRP. Diacylglycerol is the endogenous TRP agonist. ATP lowers the channel activity, the ATP effect is completely abolished by inhibition of the enzyme Drosophila melanogaster