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Literature summary extracted from

  • Reimao-Pinto, M.M.; Ignatova, V.; Burkard, T.R.; Hung, J.H.; Manzenreither, R.A.; Sowemimo, I.; Herzog, V.A.; Reichholf, B.; Farina-Lopez, S.; Ameres, S.L.
    Uridylation of RNA hairpins by tailor confines the emergence of microRNAs in Drosophila (2015), Mol. Cell, 59, 203-216.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.52 cytoplasm
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 Drosophila melanogaster 5737
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Organism

EC Number Organism UniProt Comment Textmining
2.7.7.52 Drosophila melanogaster Q9VI58
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.52 UTP + RNAn
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 Drosophila melanogaster diphosphate + RNAn+1 enzyme preferentially uridylates mirtron hairpins ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.52 terminal uridylyltransferase Tailor
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 Drosophila melanogaster
2.7.7.52 TNTase CG1091
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.7.52 physiological function isoform Tailor preferentially uridylates mirtron hairpins, thereby impeding the production of non-canonical microRNAs. Mirtron selectivity is explained by primary sequence specificity of Tailor, selecting substrates ending with a 3'-guanosine. In contrast to mirtrons, conserved Drosophila precursor micro-RNAs are significantly depleted in 3'-guanosine, thereby escaping regulatory uridylation. Cytoplasmic Tailor is required for miRNA uridylation and normal fertility in flies Drosophila melanogaster