Literature summary extracted from
Grintsevich, E.E.; Yesilyurt, H.G.; Rich, S.K.; Hung, R.J.; Terman, J.R.; Reisler, E.
F-actin dismantling through a redox-driven synergy between Mical and cofilin (2016), Nat. Cell Biol., 18, 876-885.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
1.14.13.225 |
cofilin |
cofilin enhances Mical-mediated actin filament disassembly. Mical and cofilin synergize to drive Semaphorin-Plexin repulsive signalling and axon guidance |
Drosophila melanogaster |
|
1.14.13.225 |
F-actin |
actin regulatory protein cofilin strongly suppresses the ability of F-actin to trigger Mical-mediated NADPH consumption |
Drosophila melanogaster |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.14.13.225 |
Drosophila melanogaster |
Q86BA1 |
- |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.14.13.225 |
physiological function |
F-actin is efficiently dismantled through a post-translational-mediated synergism between cofilin and the actin-oxidizing enzyme Mical. Mical-mediated oxidation of actin improves cofilin binding to filaments, where their combined effect dramatically accelerates F-actin disassembly compared with either effector alone. This synergism is also necessary and sufficient for F-actin disassembly in vivo, magnifying the effects of both Mical and cofilin on cellular remodelling, axon guidance and Semaphorin-Plexin repulsion |
Drosophila melanogaster |