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Literature summary extracted from
- The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues (2013), Biochim. Biophys. Acta, 1827, 401-410.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.5.3 | D-glyceraldehyde 3-phosphate | - |
Rattus norvegicus |  |
| 1.1.5.3 | D-glycerol phosphate | - |
Rattus norvegicus | |
| 1.1.5.3 | D-phosphoglyceric acid | - |
Rattus norvegicus | |
| 1.1.5.3 | L-Glyceraldehyde 3-phosphate | - |
Rattus norvegicus | |
| 1.1.5.3 | palmitoyl-CoA | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.5.3 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.5.3 | Ca2+ | activates | Rattus norvegicus | |
| 1.1.5.3 | Cd2+ | activates | Rattus norvegicus | |
| 1.1.5.3 | Mg2+ | activates | Rattus norvegicus | |
| 1.1.5.3 | Mn2+ | activates | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.5.3 | 74000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.5.3 | sn-glycerol 3-phosphate + coenzyme Q0 | Rattus norvegicus | - |
dihydroxyacetone phosphate + reduced coenzyme Q0 | - |
? | |
| 1.1.5.3 | sn-glycerol 3-phosphate + coenzyme Q1 | Rattus norvegicus | - |
dihydroxyacetone phosphate + reduced coenzyme Q1 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.5.3 | Rattus norvegicus | P35571 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.5.3 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.5.3 | sn-glycerol 3-phosphate + coenzyme Q0 | - |
Rattus norvegicus | dihydroxyacetone phosphate + reduced coenzyme Q0 | - |
? | |
| 1.1.5.3 | sn-glycerol 3-phosphate + coenzyme Q1 | - |
Rattus norvegicus | dihydroxyacetone phosphate + reduced coenzyme Q1 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.5.3 | monomer | 1 * 74000, calculated from amino acid sequence | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.5.3 | mGPDH | - |
Rattus norvegicus |
| 1.1.5.3 | mitochondrial glycerol-3-phosphate dehydrogenase | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.5.3 | FAD | - |
Rattus norvegicus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.5.3 | metabolism | the enzyme is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle it functions at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism | Rattus norvegicus |
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Release 2023.1 (January 2023)
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