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Literature summary extracted from

  • Hagras, A.; Toraih, E.; Fawzy, M.
    Mobile phones electromagnetic radiation and NAD (2016), Biochim. Open, 3, 19-25.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.41 diagnostics enzyme NAD+-dependent isocitrate dehydrogenase cann act as a mitochondrial marker in asthenozoospermia Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.41 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Homo sapiens
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 spermatozoon
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 isocitrate + NAD+
-
 Homo sapiens 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.41 heterotetramer (alpha)2betagamma Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.41 NAD+-dependent isocitrate dehydrogenase
-
 Homo sapiens
1.1.1.41 NAD+-IDH
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.41 37
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.41 malfunction IDH activity is increased in patients with prolonged cell phone daily use over 4 h/day. Its level correlates negatively with either the motility ratio percentages or the progressive motility percentages in the study groups. NAD+-IDH in human seminal plasma can be one of seminal plasma biomarkers reflecting the mitochondrial function of spermatozoa. Alteration of its level reflect the defective motility of sperms among some cases of cellular phone users Homo sapiens
1.1.1.41 metabolism NAD-IDH is a key enzyme in the tricarboxylic acid cycle Homo sapiens