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Literature summary extracted from

  • Suga, K.; Hamasaki, A.; Chinzaka, J.; Umakoshi, H.
    Liposomes modified with cardiolipin can act as a platform to regulate the potential flux of NADP (2016), Metab. Eng. Commun., 3, 8-14.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.42 liposome ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes did not affect the activity of ICDH Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 liposome ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes do not affect the activity of ICDH Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Homo sapiens
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Homo sapiens 2-oxoglutarate + CO2 + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 ICDH
-
 Homo sapiens
1.1.1.42 NADP+-dependent ICDH
-
 Homo sapiens
1.1.1.42 NADP+-dependent isocitrate dehydrogenase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.42 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.42 7.3
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Homo sapiens
1.1.1.42 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.42 physiological function membranes in cardiolipin-modified liposomes are dehydrated by ICDH binding. Liposomes induce a conformational change in ICDH, indicating that cardiolipin-rich membrane domains can inhibit ICDH activity. Lipid membranes, including cardiolipin molecules, can act as a platform to regulate ICDH-related metabolic pathways such as the tricarboxylic acid cycle and lipid synthesis Homo sapiens