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Literature summary extracted from

  • Escudero, L.; Al-Refai, M.; Nieto, C.; Laatsch, H.; Malpartida, F.; Seco, E.M.
    New rimocidin/CE-108 derivatives obtained by a crotonyl-CoA carboxylase/reductase gene disruption in Streptomyces diastaticus var. 108: substrates for the polyene carboxamide synthase PcsA (2015), PLoS ONE, 10, e0135891.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.85 expressed in Escherichia coli JM101 cells Streptomyces diastaticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.85 crotonyl-CoA + CO2 + NADPH + H+ Streptomyces diastaticus
-
 (2S)-ethylmalonyl-CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.85 Streptomyces diastaticus Q6T2B7 variant 108
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.85 crotonyl-CoA + CO2 + NADPH + H+
-
 Streptomyces diastaticus (2S)-ethylmalonyl-CoA + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.85 CCR
-
 Streptomyces diastaticus
1.3.1.85 crotonyl-CoA carboxylase/reductase
-
 Streptomyces diastaticus
1.3.1.85 rimJ
-
 Streptomyces diastaticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.85 NADPH
-
 Streptomyces diastaticus