EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.341 | to 1.81 A resolution, structure reveals a unique demethylase fold and a canonical folate-binding domain | Sphingomonas paucimobilis |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.341 | H60A | 97-99% loss of activity | Sphingomonas paucimobilis |
2.1.1.341 | M61A | 97-99% loss of activity | Sphingomonas paucimobilis |
2.1.1.341 | R122A | 97-99% loss of activity | Sphingomonas paucimobilis |
2.1.1.341 | R122A/R147A | complete loss of activity | Sphingomonas paucimobilis |
2.1.1.341 | Y247F | almost complete loss of activity, no discernible effect on overall protein fold or solution behavior | Sphingomonas paucimobilis |
2.1.1.341 | Y29A | 97-99% loss of activity | Sphingomonas paucimobilis |
2.1.1.341 | Y31A | 97-99% loss of activity | Sphingomonas paucimobilis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.341 | 5-methyltetrahydrofolate | competitive with respect to tetrahydrofolate, noncompetitive with respect to vanillate | Sphingomonas paucimobilis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.341 | 0.63 | - |
vanillate | pH 8.0, 30°C | Sphingomonas paucimobilis | |
2.1.1.341 | 0.72 | - |
tetrahydrofolate | pH 8.0, 30°C | Sphingomonas paucimobilis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.341 | Sphingomonas paucimobilis | Q60FX1 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.341 | additional information | enzyme uses an ordered sequential mechanism | Sphingomonas paucimobilis | ? | - |
? | |
2.1.1.341 | vanillate + tetrahydrofolate | - |
Sphingomonas paucimobilis | protocatechuate + 5-methyltetrahydrofolate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.341 | LigM | - |
Sphingomonas paucimobilis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.341 | 30 | - |
- |
Sphingomonas paucimobilis |
EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.341 | 10 | 40 | - |
Sphingomonas paucimobilis |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.341 | 50 | - |
inactive above | Sphingomonas paucimobilis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.341 | 5.76 | - |
vanillate | pH 8.0, 30°C | Sphingomonas paucimobilis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.341 | 8 | - |
- |
Sphingomonas paucimobilis |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.341 | 6 | 8 | - |
Sphingomonas paucimobilis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.341 | 0.1 | - |
5-methyltetrahydrofolate | substrate vanillate, pH 8.0, 30°C | Sphingomonas paucimobilis | |
2.1.1.341 | 0.17 | - |
5-methyltetrahydrofolate | substrate tetrahydrofolate, pH 8.0, 30°C | Sphingomonas paucimobilis |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.341 | 8 | - |
tetrahydrofolate | pH 8.0, 30°C | Sphingomonas paucimobilis | |
2.1.1.341 | 9.14 | - |
vanillate | pH 8.0, 30°C | Sphingomonas paucimobilis |