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Literature summary extracted from

  • Phillips, I.R.; Shephard, E.A.
    Drug metabolism by flavin-containing monooxygenases of human and mouse (2017), Expert. Opin. Drug Metab. Toxicol., 13, 167-181 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Homo sapiens
-
-
-
1.14.13.8 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 kidney isoform FMO1 Homo sapiens
-
1.14.13.8 kidney isoforms FMO1 and FMO5 Mus musculus
-
1.14.13.8 liver isoforms FMO1, FMO3 and FMO5 Mus musculus
-
1.14.13.8 liver isoforms FMO3 and FMO5 Homo sapiens
-
1.14.13.8 lung isoform FMO2 Homo sapiens
-
1.14.13.8 lung isoforms FMO1 and FMO2 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 (R)-metamphetamine + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens (R)-metamphetamine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 (S)-metamphetamine + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens (S)-metamphetamine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 5,6-dimethylxanthenone-4-acetic acid + NADPH + H+ + O2 substrate of isoform FMO3, methyl hydroxylation Homo sapiens ?
-
 ?
1.14.13.8 9-hydroxy-5,6-dimethyl-N-(2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 2-(9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamido)-N,N-dimethylethan-1-amine oxide + NADP+ + H2O
-
 ?
1.14.13.8 albendazole + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens albendazole S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 almotriptan + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens almotriptan N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 amphetamine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens amphetamine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 benzydamine + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens benzydamine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 cimetidine + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens cimetidine S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 clozapine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens clozapine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 contezolid + NADPH + H+ + O2 substrate of isoform FMO5 Homo sapiens contezolid N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 danusertib + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens danusertib N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 dasatinib + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-1-(2-hydroxyethyl)piperazine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 deprenyl + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens deprenyl N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 E-7016 + NADPH + H+ + O2 substrate of isoform FMO5, Bayer Villiger oxidation Homo sapiens ?
-
 ?
1.14.13.8 ethionamide + NADPH + H+ + O2 substrate of isoforms FMO1, FMO2, and FMO3 Homo sapiens ethionamide S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 GSK5182 + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens (Z)-2-(4-(5-hydroxy-1-(4-hydroxyphenyl)-2-phenylpent-1-en-1-yl)phenoxy)-N,N-dimethylethan-1-amine oxide + NADP+ + H2O
-
 ?
1.14.13.8 imipramine + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens imipramine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 itopride + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens itopride N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 K11777 + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens K11777 N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 L-775,606 + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 4-(3-(5-(4H-1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-1-(3-fluorophenethyl)piperazine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 lorcaserin + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens lorcaserin N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 loxapine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)-1-methylpiperazine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 methimazole + NADPH + H+ + O2 substrate of isoforms FMO1, FMO2, and FMO3 Homo sapiens methimazole S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 MK-0457 + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens MK-0457 N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 MK-0767 methyl sulfide + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens ?
-
 ?
1.14.13.8 moclobemide + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens moclobemide N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 N,N-diallyltryptamine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens N,N-diallyltryptamine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 N-(3R)-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3-c]pyridine-5-carboxamide + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens (R)-3-(furo[2,3-c]pyridine-5-carboxamido)quinuclidine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 N-deacetyl ketoconazole + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens N-deacetyl ketoconazole N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 N-deacetyl ketoconazole + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens N-deacetyl ketoconazole N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 nicotine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens (S)-nicotine N1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 nomifensine + NADPH + H+ + O2 substrate of isoforms FMO3 and FMO5 Homo sapiens ?
-
 ?
1.14.13.8 NSC645809 + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens N,N-diethyl-2-((8-hydroxy-6-oxo-6H-imidazo[4,5,1-de]acridin-5-yl)amino)ethan-1-amine oxide + NADP+ + H2O
-
 ?
1.14.13.8 olanzapine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 olopatadine + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens olopatadine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 pargyline + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens pargyline N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 phospho-sulindac + NADPH + H+ + O2 substrate of isoforms FMO1, FMO3, and FMO5 Homo sapiens ?
-
 ?
1.14.13.8 primaquine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens ?
-
 ?
1.14.13.8 pyrazolacridine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens pyrazolacridine N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 quazepam + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one + NADP+ + H2O
-
 ?
1.14.13.8 ranitidine + NADPH + H+ + O2 substrate of isoforms FMO3 and FMO5, S-oxygenation and N-oxygenation Homo sapiens ?
-
 ?
1.14.13.8 S-methyl esonarimod + NADPH + H+ + O2 substrate of isoforms FMO1, FMO3, and FMO5 Homo sapiens S-methyl esonarimod S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 S-methyl N,N-diethyldithiocarbamate + NADPH + H+ + O2 substrate of isoform FMO1 and FMO3 Homo sapiens (diethylnitroryl)(methylsulfanyl)methanethione + NADP+ + H2O
-
 ?
1.14.13.8 selenomethionine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens seleno-L-methionine Se-oxide + NADP+ + H2O
-
 ?
1.14.13.8 SNI-2011 + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens SNI-2011 N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 sulindac sulfide + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens ?
-
 ?
1.14.13.8 tamoxifen + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens tamoxifen N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 tazarotenic acid + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens tazarotenate N-oxide + NADP+ + H2O
-
 ?
1.14.13.8 TG100435 + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 1-(2-(4-((7-(2,6-dichlorophenyl)-5-methylbenzo[e][1,2,4]triazin-3-yl)amino)phenoxy)ethyl)pyrrolidine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 TG100435 + NADPH + H+ + O2 substrate of isoform FMO1 Homo sapiens ?
-
 ?
1.14.13.8 thiacetazone + NADPH + H+ + O2 substrate of isoforms FMO1, FMO2, and FMO3 Homo sapiens thiacetazone S-oxide + NADP+ + H2O
-
 ?
1.14.13.8 trifluoroperazine + NADPH + H+ + O2 substrate of isoform FMO3 Homo sapiens 2,3,4-trifluoropyridine 1-oxide + NADP+ + H2O
-
 ?
1.14.13.8 voriconazole + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens ?
-
 ?
1.14.13.8 xanomeline + NADPH + H+ + O2 substrate of isoforms FMO1 and FMO3 Homo sapiens xanomeline N-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 FMO1 isoform Mus musculus
1.14.13.8 FMO1 isoform Homo sapiens
1.14.13.8 FMO2 isoform Mus musculus
1.14.13.8 FMO2 isoform Homo sapiens
1.14.13.8 FMO3 isoform Mus musculus
1.14.13.8 FMO3 isoform Homo sapiens
1.14.13.8 FMO4 isoform Mus musculus
1.14.13.8 FMO4 isoform Homo sapiens
1.14.13.8 FMO5 isoform Mus musculus
1.14.13.8 FMO5 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 FAD
-
 Mus musculus
1.14.13.8 FAD
-
 Homo sapiens
1.14.13.8 NADPH
-
 Mus musculus
1.14.13.8 NADPH
-
 Homo sapiens