BRENDA - Enzyme Database show

Drug metabolism by flavin-containing monooxygenases of human and mouse

Phillips, I.R.; Shephard, E.A.; Expert. Opin. Drug Metab. Toxicol. 13, 167-181 (2017)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.13.8
Homo sapiens
-
-
-
1.14.13.8
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.13.8
kidney
isoform FMO1
Homo sapiens
-
1.14.13.8
kidney
isoforms FMO1 and FMO5
Mus musculus
-
1.14.13.8
liver
isoforms FMO3 and FMO5
Homo sapiens
-
1.14.13.8
liver
isoforms FMO1, FMO3 and FMO5
Mus musculus
-
1.14.13.8
lung
isoform FMO2
Homo sapiens
-
1.14.13.8
lung
isoforms FMO1 and FMO2
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.13.8
(R)-metamphetamine + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
(R)-metamphetamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
(S)-metamphetamine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
(S)-metamphetamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
5,6-dimethylxanthenone-4-acetic acid + NADPH + H+ + O2
substrate of isoform FMO3, methyl hydroxylation
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
9-hydroxy-5,6-dimethyl-N-(2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
2-(9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamido)-N,N-dimethylethan-1-amine oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
albendazole + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
albendazole S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
almotriptan + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
almotriptan N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
amphetamine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
amphetamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
benzydamine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
benzydamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
cimetidine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
cimetidine S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
clozapine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
clozapine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
contezolid + NADPH + H+ + O2
substrate of isoform FMO5
742463
Homo sapiens
contezolid N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
danusertib + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
danusertib N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
dasatinib + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-1-(2-hydroxyethyl)piperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
deprenyl + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
deprenyl N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
E-7016 + NADPH + H+ + O2
substrate of isoform FMO5, Bayer Villiger oxidation
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
ethionamide + NADPH + H+ + O2
substrate of isoforms FMO1, FMO2, and FMO3
742463
Homo sapiens
ethionamide S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
GSK5182 + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
(Z)-2-(4-(5-hydroxy-1-(4-hydroxyphenyl)-2-phenylpent-1-en-1-yl)phenoxy)-N,N-dimethylethan-1-amine oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
imipramine + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
imipramine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
itopride + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
itopride N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
K11777 + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
K11777 N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
L-775,606 + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
4-(3-(5-(4H-1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-1-(3-fluorophenethyl)piperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
lorcaserin + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
lorcaserin N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
loxapine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)-1-methylpiperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
methimazole + NADPH + H+ + O2
substrate of isoforms FMO1, FMO2, and FMO3
742463
Homo sapiens
methimazole S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
MK-0457 + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
MK-0457 N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
MK-0767 methyl sulfide + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
moclobemide + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
moclobemide N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N,N-diallyltryptamine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
N,N-diallyltryptamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N-(3R)-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3-c]pyridine-5-carboxamide + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
(R)-3-(furo[2,3-c]pyridine-5-carboxamido)quinuclidine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N-deacetyl ketoconazole + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
N-deacetyl ketoconazole N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N-deacetyloxoconazole + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
N-deacetyl ketoconazole N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
nicotine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
(S)-nicotine N1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
nomifensine + NADPH + H+ + O2
substrate of isoforms FMO3 and FMO5
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
NSC645809 + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
N,N-diethyl-2-((8-hydroxy-6-oxo-6H-imidazo[4,5,1-de]acridin-5-yl)amino)ethan-1-amine oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
olanzapine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
olopatadine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
olopatadine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
pargyline + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
pargyline N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
phospho-sulindac + NADPH + H+ + O2
substrate of isoforms FMO1, FMO3, and FMO5
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
primaquine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
pyrazolacridine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
pyrazolacridine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
quazepam + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one + NADP+ + H2O
-
-
-
?
1.14.13.8
ranitidine + NADPH + H+ + O2
substrate of isoforms FMO3 and FMO5, S-oxygenation and N-oxygenation
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
S-methyl esonarimod + NADPH + H+ + O2
substrate of isoforms FMO1, FMO3, and FMO5
742463
Homo sapiens
S-methyl esonarimod S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
S-methyl N,N-diethyldithiocarbamate + NADPH + H+ + O2
substrate of isoform FMO1 and FMO3
742463
Homo sapiens
(diethylnitroryl)(methylsulfanyl)methanethione + NADP+ + H2O
-
-
-
?
1.14.13.8
selenomethionine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
seleno-L-methionine Se-oxideoxide + NADP+ + H2O
-
-
-
?
1.14.13.8
SNI-2011 + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
SNI-2011 N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
sulindac sulfide + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
tamoxifen + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
tamoxifen N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
tazarotenic acid + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
tazarotenate N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
TG100435 + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
1-(2-(4-((7-(2,6-dichlorophenyl)-5-methylbenzo[e][1,2,4]triazin-3-yl)amino)phenoxy)ethyl)pyrrolidine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
TG100435 + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
thiacetazone + NADPH + H+ + O2
substrate of isoforms FMO1, FMO2, and FMO3
742463
Homo sapiens
thiacetazone S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
trifluoroperazine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
2,3,4-trifluoropyridine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
voriconazole + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
xanomeline + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
xanomeline N-oxide + NADP+ + H2O
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.14.13.8
FAD
-
Homo sapiens
1.14.13.8
FAD
-
Mus musculus
1.14.13.8
NADPH
-
Homo sapiens
1.14.13.8
NADPH
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.14.13.8
FAD
-
Homo sapiens
1.14.13.8
FAD
-
Mus musculus
1.14.13.8
NADPH
-
Homo sapiens
1.14.13.8
NADPH
-
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.13.8
kidney
isoform FMO1
Homo sapiens
-
1.14.13.8
kidney
isoforms FMO1 and FMO5
Mus musculus
-
1.14.13.8
liver
isoforms FMO3 and FMO5
Homo sapiens
-
1.14.13.8
liver
isoforms FMO1, FMO3 and FMO5
Mus musculus
-
1.14.13.8
lung
isoform FMO2
Homo sapiens
-
1.14.13.8
lung
isoforms FMO1 and FMO2
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.13.8
(R)-metamphetamine + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
(R)-metamphetamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
(S)-metamphetamine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
(S)-metamphetamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
5,6-dimethylxanthenone-4-acetic acid + NADPH + H+ + O2
substrate of isoform FMO3, methyl hydroxylation
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
9-hydroxy-5,6-dimethyl-N-(2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
2-(9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamido)-N,N-dimethylethan-1-amine oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
albendazole + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
albendazole S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
almotriptan + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
almotriptan N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
amphetamine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
amphetamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
benzydamine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
benzydamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
cimetidine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
cimetidine S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
clozapine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
clozapine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
contezolid + NADPH + H+ + O2
substrate of isoform FMO5
742463
Homo sapiens
contezolid N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
danusertib + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
danusertib N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
dasatinib + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-1-(2-hydroxyethyl)piperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
deprenyl + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
deprenyl N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
E-7016 + NADPH + H+ + O2
substrate of isoform FMO5, Bayer Villiger oxidation
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
ethionamide + NADPH + H+ + O2
substrate of isoforms FMO1, FMO2, and FMO3
742463
Homo sapiens
ethionamide S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
GSK5182 + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
(Z)-2-(4-(5-hydroxy-1-(4-hydroxyphenyl)-2-phenylpent-1-en-1-yl)phenoxy)-N,N-dimethylethan-1-amine oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
imipramine + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
imipramine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
itopride + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
itopride N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
K11777 + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
K11777 N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
L-775,606 + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
4-(3-(5-(4H-1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-1-(3-fluorophenethyl)piperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
lorcaserin + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
lorcaserin N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
loxapine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)-1-methylpiperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
methimazole + NADPH + H+ + O2
substrate of isoforms FMO1, FMO2, and FMO3
742463
Homo sapiens
methimazole S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
MK-0457 + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
MK-0457 N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
MK-0767 methyl sulfide + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
moclobemide + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
moclobemide N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N,N-diallyltryptamine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
N,N-diallyltryptamine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N-(3R)-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3-c]pyridine-5-carboxamide + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
(R)-3-(furo[2,3-c]pyridine-5-carboxamido)quinuclidine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N-deacetyl ketoconazole + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
N-deacetyl ketoconazole N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
N-deacetyloxoconazole + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
N-deacetyl ketoconazole N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
nicotine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
(S)-nicotine N1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
nomifensine + NADPH + H+ + O2
substrate of isoforms FMO3 and FMO5
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
NSC645809 + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
N,N-diethyl-2-((8-hydroxy-6-oxo-6H-imidazo[4,5,1-de]acridin-5-yl)amino)ethan-1-amine oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
olanzapine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
olopatadine + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
olopatadine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
pargyline + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
pargyline N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
phospho-sulindac + NADPH + H+ + O2
substrate of isoforms FMO1, FMO3, and FMO5
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
primaquine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
pyrazolacridine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
pyrazolacridine N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
quazepam + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one + NADP+ + H2O
-
-
-
?
1.14.13.8
ranitidine + NADPH + H+ + O2
substrate of isoforms FMO3 and FMO5, S-oxygenation and N-oxygenation
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
S-methyl esonarimod + NADPH + H+ + O2
substrate of isoforms FMO1, FMO3, and FMO5
742463
Homo sapiens
S-methyl esonarimod S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
S-methyl N,N-diethyldithiocarbamate + NADPH + H+ + O2
substrate of isoform FMO1 and FMO3
742463
Homo sapiens
(diethylnitroryl)(methylsulfanyl)methanethione + NADP+ + H2O
-
-
-
?
1.14.13.8
selenomethionine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
seleno-L-methionine Se-oxideoxide + NADP+ + H2O
-
-
-
?
1.14.13.8
SNI-2011 + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
SNI-2011 N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
sulindac sulfide + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
tamoxifen + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
tamoxifen N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
tazarotenic acid + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
tazarotenate N-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
TG100435 + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
1-(2-(4-((7-(2,6-dichlorophenyl)-5-methylbenzo[e][1,2,4]triazin-3-yl)amino)phenoxy)ethyl)pyrrolidine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
TG100435 + NADPH + H+ + O2
substrate of isoform FMO1
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
thiacetazone + NADPH + H+ + O2
substrate of isoforms FMO1, FMO2, and FMO3
742463
Homo sapiens
thiacetazone S-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
trifluoroperazine + NADPH + H+ + O2
substrate of isoform FMO3
742463
Homo sapiens
2,3,4-trifluoropyridine 1-oxide + NADP+ + H2O
-
-
-
?
1.14.13.8
voriconazole + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
?
-
-
-
?
1.14.13.8
xanomeline + NADPH + H+ + O2
substrate of isoforms FMO1 and FMO3
742463
Homo sapiens
xanomeline N-oxide + NADP+ + H2O
-
-
-
?