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Literature summary extracted from

  • Schlotawa, L.; Steinfeld, R.; von Figura, K.; Dierks, T.; Gaertner, J.
    Molecular analysis of SUMF1 mutations stability and residual activity of mutant formylglycine-generating enzyme determine disease severity in multiple sulfatase deficiency (2008), Hum. Mutat., 29, 205 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.8.3.7 A177P the mutant shows 0.6% of wild type activity Homo sapiens
1.8.3.7 A279V the mutant shows 22.9% of wild type activity Homo sapiens
1.8.3.7 R349W the mutant shows 0.5% of wild type activity Homo sapiens
1.8.3.7 W179S the mutant shows 2.7% of wild type activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.3.7 endoplasmic reticulum
-
Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.3.7 a [sulfatase]-L-cysteine + O2 + a thiol Homo sapiens
-
a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.7 Homo sapiens Q8NBK3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.3.7 MonoQ column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.3.7 HT-1080 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.7 a [sulfatase]-L-cysteine + O2 + a thiol
-
Homo sapiens a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.8.3.7 ? x * 38000, secreted enzyme, SDS-PAGE Homo sapiens
1.8.3.7 ? x * 41000, full-length enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.8.3.7 FGE
-
Homo sapiens
1.8.3.7 SUMF1
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.8.3.7 malfunction multiple sulfatase deficiency is caused by mutations in the SUMF1 gene encoding the formylglycine-generating enzyme Homo sapiens
1.8.3.7 metabolism the enzyme posttranslationally activates sulfatases by generating formylglycine in their catalytic sites Homo sapiens