EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.24 | 4-hydroxybenzaldehyde | linear dead-end inhibition, competitive versus succinate semialdehyde, uncompetitive versus NAD+ | Aspergillus niger | |
1.2.1.24 | AMP | dead-end inhibition, AMP competes with NAD+ | Aspergillus niger | |
1.2.1.24 | additional information | no product inhibition by succinate | Aspergillus niger | |
1.2.1.24 | N-formylglycine | - |
Aspergillus niger | |
1.2.1.24 | NAD+ | - |
Aspergillus niger | |
1.2.1.24 | NADH | product inhibition, competitive versus NAD+, uncompetitive versus succinate semialdehyde | Aspergillus niger | |
1.2.1.24 | succinate semialdehyde | substrate inhibition, uncompetitive versus NAD+ | Aspergillus niger |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.24 | additional information | - |
additional information | kinetics and kinetic mechanism, overview | Aspergillus niger | |
1.2.1.24 | 0.028 | - |
succinate semialdehyde | pH 9.0 37°C | Aspergillus niger | |
1.2.1.24 | 3.1 | - |
NAD+ | pH 9.0 37°C | Aspergillus niger |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.24 | 160000 | - |
native enzyme, gel filtration | Aspergillus niger |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.24 | succinate semialdehyde + NAD+ + H2O | Aspergillus niger | - |
succinate + NADH + 2 H+ | - |
? | |
1.2.1.24 | succinate semialdehyde + NAD+ + H2O | Aspergillus niger NCIM 565 | - |
succinate + NADH + 2 H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.24 | Aspergillus niger | A2R4V5 | - |
- |
1.2.1.24 | Aspergillus niger NCIM 565 | A2R4V5 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.24 | native enzyme 9fold from mycelia by ammonium sulfate fractionation, hydrophobic interaction and anion exchange chromatography | Aspergillus niger |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.2.1.24 | succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ | sequential ordered Bi-Bi reaction mechanism | Aspergillus niger |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.24 | mycelium | grown on gamma-aminobutyric acid | Aspergillus niger | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.24 | 0.277 | - |
purified enzyme, pH 9.0, 37°C | Aspergillus niger |
EC Number | Storage Stability | Organism |
---|---|---|
1.2.1.24 | -20°C, purified native enzyme, 100 mM diphosphate, pH 8.0, 14 mM 2-mercaptoethanol, 20% glycerol, loss of 50% activity witin 5 days | Aspergillus niger |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.24 | succinate semialdehyde + NAD+ + H2O | - |
Aspergillus niger | succinate + NADH + 2 H+ | - |
? | |
1.2.1.24 | succinate semialdehyde + NAD+ + H2O | the enzyme is specific for the substrates | Aspergillus niger | succinate + NADH + 2 H+ | - |
? | |
1.2.1.24 | succinate semialdehyde + NAD+ + H2O | - |
Aspergillus niger NCIM 565 | succinate + NADH + 2 H+ | - |
? | |
1.2.1.24 | succinate semialdehyde + NAD+ + H2O | the enzyme is specific for the substrates | Aspergillus niger NCIM 565 | succinate + NADH + 2 H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.24 | homotetramer | 4 * 44000, SDS-PAGE | Aspergillus niger |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.24 | SSADH | - |
Aspergillus niger |
1.2.1.24 | succinic semialdehyde dehydrogenase | - |
Aspergillus niger |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.24 | 30 | 35 | - |
Aspergillus niger |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.24 | 9 | 10 | - |
Aspergillus niger |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.24 | additional information | no activity with NADP+ | Aspergillus niger | |
1.2.1.24 | NAD+ | absolutely specific for | Aspergillus niger |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.24 | additional information | - |
additional information | inhibition kinetics | Aspergillus niger | |
1.2.1.24 | 0.44 | - |
NADH | pH 9.0, 37°C, versus succinate semmialdehyde | Aspergillus niger | |
1.2.1.24 | 0.55 | - |
NADH | pH 9.0, 37°C, versus NAD+ | Aspergillus niger | |
1.2.1.24 | 2.3 | - |
NAD+ | pH 9.0, 37°C | Aspergillus niger | |
1.2.1.24 | 3.37 | - |
4-hydroxybenzaldehyde | pH 9.0, 37°C, versus succinate semmialdehyde | Aspergillus niger | |
1.2.1.24 | 3.9 | - |
4-hydroxybenzaldehyde | pH 9.0, 37°C, versus NAD+ | Aspergillus niger | |
1.2.1.24 | 22.95 | - |
AMP | pH 9.0, 37°C, versus NAD+ | Aspergillus niger | |
1.2.1.24 | 31.76 | - |
AMP | pH 9.0, 37°C, versus succinate semmialdehyde | Aspergillus niger |