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Literature summary extracted from

  • Kumar, S.; Kumar, S.; Punekar, N.S.
    Characterization of succinic semialdehyde dehydrogenase from Aspergillus niger (2015), Indian J. Exp. Biol., 53, 67-74 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.24 4-hydroxybenzaldehyde linear dead-end inhibition, competitive versus succinate semialdehyde, uncompetitive versus NAD+ Aspergillus niger
1.2.1.24 AMP dead-end inhibition, AMP competes with NAD+ Aspergillus niger
1.2.1.24 additional information no product inhibition by succinate Aspergillus niger
1.2.1.24 N-formylglycine
-
Aspergillus niger
1.2.1.24 NAD+
-
Aspergillus niger
1.2.1.24 NADH product inhibition, competitive versus NAD+, uncompetitive versus succinate semialdehyde Aspergillus niger
1.2.1.24 succinate semialdehyde substrate inhibition, uncompetitive versus NAD+ Aspergillus niger

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 additional information
-
additional information kinetics and kinetic mechanism, overview Aspergillus niger
1.2.1.24 0.028
-
succinate semialdehyde pH 9.0 37°C Aspergillus niger
1.2.1.24 3.1
-
NAD+ pH 9.0 37°C Aspergillus niger

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.24 160000
-
native enzyme, gel filtration Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.24 succinate semialdehyde + NAD+ + H2O Aspergillus niger
-
succinate + NADH + 2 H+
-
?
1.2.1.24 succinate semialdehyde + NAD+ + H2O Aspergillus niger NCIM 565
-
succinate + NADH + 2 H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Aspergillus niger A2R4V5
-
-
1.2.1.24 Aspergillus niger NCIM 565 A2R4V5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.24 native enzyme 9fold from mycelia by ammonium sulfate fractionation, hydrophobic interaction and anion exchange chromatography Aspergillus niger

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.24 succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ sequential ordered Bi-Bi reaction mechanism Aspergillus niger

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 mycelium grown on gamma-aminobutyric acid Aspergillus niger
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.24 0.277
-
purified enzyme, pH 9.0, 37°C Aspergillus niger

Storage Stability

EC Number Storage Stability Organism
1.2.1.24 -20°C, purified native enzyme, 100 mM diphosphate, pH 8.0, 14 mM 2-mercaptoethanol, 20% glycerol, loss of 50% activity witin 5 days Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
Aspergillus niger succinate + NADH + 2 H+
-
?
1.2.1.24 succinate semialdehyde + NAD+ + H2O the enzyme is specific for the substrates Aspergillus niger succinate + NADH + 2 H+
-
?
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
Aspergillus niger NCIM 565 succinate + NADH + 2 H+
-
?
1.2.1.24 succinate semialdehyde + NAD+ + H2O the enzyme is specific for the substrates Aspergillus niger NCIM 565 succinate + NADH + 2 H+
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.24 homotetramer 4 * 44000, SDS-PAGE Aspergillus niger

Synonyms

EC Number Synonyms Comment Organism
1.2.1.24 SSADH
-
Aspergillus niger
1.2.1.24 succinic semialdehyde dehydrogenase
-
Aspergillus niger

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.24 30 35
-
Aspergillus niger

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.24 9 10
-
Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 additional information no activity with NADP+ Aspergillus niger
1.2.1.24 NAD+ absolutely specific for Aspergillus niger

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.24 additional information
-
additional information inhibition kinetics Aspergillus niger
1.2.1.24 0.44
-
NADH pH 9.0, 37°C, versus succinate semmialdehyde Aspergillus niger
1.2.1.24 0.55
-
NADH pH 9.0, 37°C, versus NAD+ Aspergillus niger
1.2.1.24 2.3
-
NAD+ pH 9.0, 37°C Aspergillus niger
1.2.1.24 3.37
-
4-hydroxybenzaldehyde pH 9.0, 37°C, versus succinate semmialdehyde Aspergillus niger
1.2.1.24 3.9
-
4-hydroxybenzaldehyde pH 9.0, 37°C, versus NAD+ Aspergillus niger
1.2.1.24 22.95
-
AMP pH 9.0, 37°C, versus NAD+ Aspergillus niger
1.2.1.24 31.76
-
AMP pH 9.0, 37°C, versus succinate semmialdehyde Aspergillus niger