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Literature summary extracted from

  • Deris, Z.Z.; Akter, J.; Sivanesan, S.; Roberts, K.D.; Thompson, P.E.; Nation, R.L.; Li, J.; Velkov, T.
    A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity (2014), J. Antibiot., 67, 147-151 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 colistin
-
 Acinetobacter baumannii
7.1.1.2 colistin
-
 Escherichia coli
7.1.1.2 colistin
-
 Klebsiella pneumoniae
7.1.1.2 Polymyxin B
-
 Acinetobacter baumannii
7.1.1.2 Polymyxin B mixed inhibition with respect to ubiquinone-1 and non-competitive inhibition with respect to NADH Escherichia coli
7.1.1.2 Polymyxin B
-
 Klebsiella pneumoniae
7.1.1.2 polymyxin B1
-
 Escherichia coli
7.1.1.2 polymyxin B2
-
 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 membrane
-
 Escherichia coli 16020
-
7.1.1.2 membrane
-
 Klebsiella pneumoniae 16020
-
7.1.1.2 membrane
-
 Acinetobacter baumannii 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Acinetobacter baumannii
-
-
-
7.1.1.2 Acinetobacter baumannii ATCC 19606
-
-
-
7.1.1.2 Escherichia coli
-
-
-
7.1.1.2 Escherichia coli DH5alpha
-
-
-
7.1.1.2 Klebsiella pneumoniae
-
-
-
7.1.1.2 Klebsiella pneumoniae ATCC 13883
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone-1 + 5 H+[side 1]
-
 Escherichia coli NAD+ + ubiquinol-1 + 4 H+[side 2]
-
 ?
7.1.1.2 NADH + ubiquinone-1 + 5 H+[side 1]
-
 Escherichia coli DH5alpha NAD+ + ubiquinol-1 + 4 H+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 NDH-2
-
 Escherichia coli
7.1.1.2 NDH-2
-
 Klebsiella pneumoniae
7.1.1.2 NDH-2
-
 Acinetobacter baumannii

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 0.045
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli polymyxin B1
7.1.1.2 0.05
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli Polymyxin B
7.1.1.2 0.057
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli polymyxin B2
7.1.1.2 0.167
-
 pH not specified in the publication, temperature not specified in the publication Acinetobacter baumannii Polymyxin B
7.1.1.2 0.168
-
 pH not specified in the publication, temperature not specified in the publication Klebsiella pneumoniae Polymyxin B
7.1.1.2 0.251
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli colistin
7.1.1.2 0.356
-
 pH not specified in the publication, temperature not specified in the publication Acinetobacter baumannii colistin
7.1.1.2 0.376
-
 pH not specified in the publication, temperature not specified in the publication Klebsiella pneumoniae colistin