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Literature summary extracted from
- An electron transfer flavoprotein is essential for viability and its depletion causes a rod-to-sphere change in Burkholderia cenocepacia (2015), Microbiology, 161, 1909-1920 .
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.5.5.1 | additional information | construction of strain Detfdh2 K56-2 DBCAS0609 through deletion of putative ETF dehydrogenase and of strain Cetfdh1 K56-2 rhaP::BCAL1468/Tpr, showing rhamnose-dependent etfdh1 expression in K56 background, in the latter in the presence of etfdh2, lack of etfdh1 expression reduces growth to 29% of growth with rhamnose | Burkholderia cenocepacia |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.5.5.1 | mitochondrion | - |
Burkholderia cenocepacia | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | Burkholderia cenocepacia | group I electron-transferring flavoprotein, ETF | electron-transferring flavoprotein + ubiquinol | - |
? |  |
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | Burkholderia cenocepacia K56-2 | group I electron-transferring flavoprotein, ETF | electron-transferring flavoprotein + ubiquinol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.5.1 | Burkholderia cenocepacia | B4E7H3 | - |
- |
| 1.5.5.1 | Burkholderia cenocepacia | B4EP03 | - |
- |
| 1.5.5.1 | Burkholderia cenocepacia K56-2 | B4E7H3 | - |
- |
| 1.5.5.1 | Burkholderia cenocepacia K56-2 | B4EP03 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | - |
Burkholderia cenocepacia | electron-transferring flavoprotein + ubiquinol | - |
? | |
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | group I electron-transferring flavoprotein, ETF | Burkholderia cenocepacia | electron-transferring flavoprotein + ubiquinol | - |
? | |
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | - |
Burkholderia cenocepacia K56-2 | electron-transferring flavoprotein + ubiquinol | - |
? | |
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | group I electron-transferring flavoprotein, ETF | Burkholderia cenocepacia K56-2 | electron-transferring flavoprotein + ubiquinol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.5.5.1 | BCAL1468 | - |
Burkholderia cenocepacia |
| 1.5.5.1 | BCAS0609 | - |
Burkholderia cenocepacia |
| 1.5.5.1 | ETFDH | - |
Burkholderia cenocepacia |
| 1.5.5.1 | ETFDH1 | - |
Burkholderia cenocepacia |
| 1.5.5.1 | ETFDH2 | - |
Burkholderia cenocepacia |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.5.1 | FAD | - |
Burkholderia cenocepacia | |
| 1.5.5.1 | ubiquinone | - |
Burkholderia cenocepacia | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.5.5.1 | malfunction | depletion of enzyme ETFDH leads to growth inhibition in Burkholderia cenocepacia. In the DELTAetfdh2 mutant strain, growth is unaffected as long as gene etfdh1 is expressed, but falls to 13% of wild-type activity in the absence of rhamnose, suggesting that gene etfdh2 partially complements gene etfdh1. The morphology seen when EtfAB or ETF dehydrogenase is depleted is not due to a general defect of respiration | Burkholderia cenocepacia |
| 1.5.5.1 | metabolism | group I electron-transferring flavoproteins (ETFs) funnel electrons from a variety of species-specific primary dehydrogenases to the ETF dehydrogenase (ETFDH) from which they enter the electron transport chain at the ubiquinone pool. Group II ETFs divert electrons away from primary dehydrogenases towards nitrogenase reductase, overview | Burkholderia cenocepacia |
| 1.5.5.1 | physiological function | group I ETF-alpha-coding gene, etfA, and group I ETF-beta-coding gene, etfB, are essential for Burkholderia cenocepacia, ETFDH funnels electrons from ETFs to ubiquinone, entering the electron transport chain at the ubiquinone pool. ENzyme ETF dehydrogenase induces a rod-to-sphere change in morphology, like the ETFalpha/beta proteins | Burkholderia cenocepacia |
| 1.5.5.1 | physiological function | group I ETF-alpha-coding gene, etfA, and group I ETF-beta-coding gene, etfB, are essential for Burkholderia cenocepacia, ETFDH funnels electrons from ETFs to ubiquinone, entering the electron transport chain at the ubiquinone pool. Enzyme ETF dehydrogenase induces a rod-to-sphere change in morphology, like the ETFalpha/beta proteins. None of the genes found on the third chromosome of Burkholderia cenocepacia, including etfdh2, are likely to be essential | Burkholderia cenocepacia |
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Release 2023.1 (January 2023)
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