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Literature summary extracted from

  • Qu, Y.; Easson, M.L.; Froese, J.; Simionescu, R.; Hudlicky, T.; De Luca, V.
    Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast (2015), Proc. Natl. Acad. Sci. USA, 112, 6224-6229 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.99.41 16-methoxytabersonine + NADPH + H+ Catharanthus roseus
-
 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
-
 ?
1.1.99.41 tabersonine + NADPH + H+ Catharanthus roseus
-
 2,3-dihydro-3-hydroxytabersonine + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.41 Catharanthus roseus A0A161CAI1 cultivar Little Delicata
-
1.14.14.50 Catharanthus roseus I1TEM1 cultivar Little Delicata
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.41 epidermis
-
 Catharanthus roseus
-
1.1.99.41 leaf
-
 Catharanthus roseus
-
1.14.14.50 epidermis
-
 Catharanthus roseus
-
1.14.14.50 leaf
-
 Catharanthus roseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.41 16-hydroxytabersonine + NADPH + H+
-
 Catharanthus roseus ?
-
 ?
1.1.99.41 16-methoxytabersonine + NADPH + H+
-
 Catharanthus roseus 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
-
 ?
1.1.99.41 2,3-dihydrotabersonine + NADPH + H+
-
 Catharanthus roseus ?
-
 ?
1.1.99.41 tabersonine + NADPH + H+
-
 Catharanthus roseus 2,3-dihydro-3-hydroxytabersonine + NADP+
-
 ?
1.14.14.50 16-methoxytabersonine + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.50 tabersonine + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.99.41 ADHL1
-
 Catharanthus roseus
1.1.99.41 T3R
-
 Catharanthus roseus
1.1.99.41 tabersonine 3-reductas
-
 Catharanthus roseus
1.14.14.50 CYP71D1V2
-
 Catharanthus roseus
1.14.14.50 T3O
-
 Catharanthus roseus