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Literature summary extracted from

  • Wu, Z.; Lee, D.; Joo, J.; Shin, J.; Kang, W.; Oh, S.; Lee, D.; Lee, S.; Yea, S.; Lee, H.; Lee, T.; Liu, K.
    CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems (2013), Antimicrob. Agents Chemother., 57, 5448-5456 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.73 microsome
-
 Homo sapiens
-
-
1.14.14.74 microsome
-
 Homo sapiens
-
-
1.14.14.75 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.73 albendazole + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.73 fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 fenbendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.74 albendazole + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.75 fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.73 Homo sapiens P51589
-
-
1.14.14.74 Homo sapiens P51589
-
-
1.14.14.75 Homo sapiens P33261
-
-
1.14.14.75 Homo sapiens P51589
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.73 liver
-
 Homo sapiens
-
1.14.14.74 liver
-
 Homo sapiens
-
1.14.14.75 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.73 albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.73 fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens fenbendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.74 albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.75 fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.73 CYP2J2
-
 Homo sapiens
1.14.14.74 CYP2J2
-
 Homo sapiens
1.14.14.75 CYP2C19
-
 Homo sapiens
1.14.14.75 CYP2J2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.74 physiological function albendazole hydroxylation correlates with CYP2J2 activity Homo sapiens
1.14.14.75 physiological function fenbendazole hydroxylation correlates with both CYP2C19 and CYP2J2 activities Homo sapiens