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Literature summary extracted from

  • Hinder, L.; Figueroa-Romero, C.; Pacut, C.; Hong, Y.; Vivekanandan-Giri, A.; Pennathur, S.; Feldman, E.
    Long-chain acyl coenzyme a synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction (2014), Antioxid. Redox Signal., 21, 588-600 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + a long-chain fatty acid + CoA Rattus norvegicus
-
 AMP + diphosphate + a long-chain acyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus P18163
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 Schwann cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + a long-chain fatty acid + CoA
-
 Rattus norvegicus AMP + diphosphate + a long-chain acyl-CoA
-
 ?
6.2.1.3 ATP + linoleate + CoA
-
 Rattus norvegicus AMP + diphosphate + linoleoyl-CoA
-
 ?
6.2.1.3 ATP + oleate + CoA
-
 Rattus norvegicus AMP + diphosphate + oleoyl-CoA
-
 ?
6.2.1.3 ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.2.1.3 ? x * 75000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL1 isoform Rattus norvegicus
6.2.1.3 long-chain acyl coenzyme A synthetase 1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
6.2.1.3 physiological function isoform Acsl1 overexpression prevents oxidative stress (nitrotyrosine, hydroxyoctadecadienoic acids) and attenuates cellular injury in Schwann cells following 12 h exposure to long chain fatty acids Rattus norvegicus