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Literature summary extracted from

  • Li, Y.; Lai, Y.M.; Lu, Y.; Yang, Y.L.; Chen, S.
    Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba (2014), Arch. Microbiol., 196, 765-774 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.13 the enzyme is encoded in the albonoursin biosynthetic gene cluster, albABC, genes albAB encode units for a cyclic dipeptide oxidase complex, responsible for generating two dehydrogenated double bonds Nocardiopsis alba

Protein Variants

EC Number Protein Variants Comment Organism
1.3.3.13 additional information generation of an albABC gene deletion mutant YL001 of Nocardiopsis alba, genetic organization, overview. Strain YL001 show no significant difference from the wild-type in colonial morphology, and it has a slightly vibrant growth on the MS agar, production of the cyclic dipeptides is abolished in the DELTAalbABC mutant Nocardiopsis alba

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.13 cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2 Nocardiopsis alba
-
 ? + 2 H2O2
-
 ?
1.3.3.13 cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2 Nocardiopsis alba ATCC BAA-2165
-
 ? + 2 H2O2
-
 ?
1.3.3.13 cyclo(L-leucyl-L-phenylalanyl) + 2 O2 Nocardiopsis alba
-
 albonoursin + 2 H2O2
-
 ?
1.3.3.13 cyclo(L-leucyl-L-phenylalanyl) + 2 O2 Nocardiopsis alba ATCC BAA-2165
-
 albonoursin + 2 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.13 Nocardiopsis alba
-
 isolated from the guts of healthy honeybees in a year-round survey
-
1.3.3.13 Nocardiopsis alba ATCC BAA-2165
-
 isolated from the guts of healthy honeybees in a year-round survey
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.13 cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2
-
 Nocardiopsis alba ? + 2 H2O2
-
 ?
1.3.3.13 cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2
-
 Nocardiopsis alba ATCC BAA-2165 ? + 2 H2O2
-
 ?
1.3.3.13 cyclo(L-leucyl-L-phenylalanyl) + 2 O2
-
 Nocardiopsis alba albonoursin + 2 H2O2
-
 ?
1.3.3.13 cyclo(L-leucyl-L-phenylalanyl) + 2 O2
-
 Nocardiopsis alba ATCC BAA-2165 albonoursin + 2 H2O2
-
 ?
1.3.3.13 additional information albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2 Nocardiopsis alba ?
-
 ?
1.3.3.13 additional information albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2 Nocardiopsis alba ATCC BAA-2165 ?
-
 ?

General Information

EC Number General Information Comment Organism
1.3.3.13 malfunction the albABC gene operon deletion mutant of Nocariopsis alba cannot produce cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu) Nocardiopsis alba
1.3.3.13 metabolism the albonoursin biosynthetic gene cluster is involved in the regulated biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba Nocardiopsis alba
1.3.3.13 physiological function the enzyme is required for biosynthesis of antibacterial cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu) Nocardiopsis alba