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Literature summary extracted from

  • Jaenecke, F.; Friedrich-Epler, B.; Parthier, C.; Stubbs, M.T.
    Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase (2015), Biochemistry, 54, 6454-6461 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.4.4 expression of mutant enzymes in Sf9 insect cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.17.4.4 C132A mutation eliminates enzymatic activity in conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 C135A mutation eliminates enzymatic activity in conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 C16A about 85% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 40% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 C43A about 75% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 25% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 C43A/C51A about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. The deletion mutant enzyme retains 85% of the wild-type activity in the conversion of vitamin K 2,3-epoxide to vitamin K Homo sapiens
1.17.4.4 C51A mutant enzyme retains essentially wild-type activity in conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 C85A about 55% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 105% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 C96A about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 40% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
1.17.4.4 DELTAC43-C51 about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. The deletion mutant enzyme retains 112% of the wild-type activity in the conversion of vitamin K 2,3-epoxide to vitamin K Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 warfarin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 endoplasmic reticulum integral membrane enzyme of the endoplasmic reticulum Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Homo sapiens Q9BQB6 vitamin K epoxide reductase complex subunit 1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.4
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol
-
 Homo sapiens vitamin K + oxidized dithiothreitol + H2O
-
 ?
1.17.4.4 vitamin K + 1,4-dithiothreitol
-
 Homo sapiens vitamin K hydroquinone + oxidized dithiothreitol + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.4.4 VKOR
-
 Homo sapiens