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Literature summary extracted from

  • Nakipoglu, M.; Yilmaz, F.; Icgen, B.
    vanA Gene harboring enterococcal and non-enterococcal isolates expressing high level vancomycin and teicoplanin resistance reservoired in surface waters (2017), Bull. Environ. Contam. Toxicol., 98, 712-719 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas fluorescens
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecalis
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecium
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Comamonas testosteroni
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Raoultella planticola
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas plecoglossicida
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas koreensis
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecalis Cr07
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Comamonas testosteroni Ni11
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecium 330
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas plecoglossicida Ag10
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas koreensis Hg11
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas koreensis Hg10
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas fluorescens SDS3
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecalis Pb06
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecalis E07
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Raoultella planticola Ag11
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Pseudomonas koreensis Cu12
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.2.1 Comamonas testosteroni
-
-
-
6.1.2.1 Comamonas testosteroni Ni11
-
-
-
6.1.2.1 Enterococcus faecalis
-
-
-
6.1.2.1 Enterococcus faecalis Cr07
-
-
-
6.1.2.1 Enterococcus faecalis E07
-
-
-
6.1.2.1 Enterococcus faecalis Pb06
-
-
-
6.1.2.1 Enterococcus faecium
-
-
-
6.1.2.1 Enterococcus faecium 330
-
-
-
6.1.2.1 Pseudomonas fluorescens
-
-
-
6.1.2.1 Pseudomonas fluorescens SDS3
-
-
-
6.1.2.1 Pseudomonas koreensis
-
-
-
6.1.2.1 Pseudomonas koreensis Cu12
-
-
-
6.1.2.1 Pseudomonas koreensis Hg10
-
-
-
6.1.2.1 Pseudomonas koreensis Hg11
-
-
-
6.1.2.1 Pseudomonas plecoglossicida
-
-
-
6.1.2.1 Pseudomonas plecoglossicida Ag10
-
-
-
6.1.2.1 Raoultella planticola
-
-
-
6.1.2.1 Raoultella planticola Ag11
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas fluorescens D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecalis D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecium D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Comamonas testosteroni D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Raoultella planticola D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas plecoglossicida D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas koreensis D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecalis Cr07 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Comamonas testosteroni Ni11 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecium 330 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas plecoglossicida Ag10 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas koreensis Hg11 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas koreensis Hg10 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas fluorescens SDS3 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecalis Pb06 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecalis E07 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Raoultella planticola Ag11 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Pseudomonas koreensis Cu12 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.2.1 ? x * 39000, SDS-PAGE Pseudomonas fluorescens
6.1.2.1 ? x * 39000, SDS-PAGE Enterococcus faecalis
6.1.2.1 ? x * 39000, SDS-PAGE Enterococcus faecium
6.1.2.1 ? x * 39000, SDS-PAGE Comamonas testosteroni
6.1.2.1 ? x * 39000, SDS-PAGE Raoultella planticola
6.1.2.1 ? x * 39000, SDS-PAGE Pseudomonas plecoglossicida
6.1.2.1 ? x * 39000, SDS-PAGE Pseudomonas koreensis

Synonyms

EC Number Synonyms Comment Organism
6.1.2.1 D-alanine-D-lactate ligase
-
 Pseudomonas fluorescens
6.1.2.1 D-alanine-D-lactate ligase
-
 Enterococcus faecalis
6.1.2.1 D-alanine-D-lactate ligase
-
 Enterococcus faecium
6.1.2.1 D-alanine-D-lactate ligase
-
 Comamonas testosteroni
6.1.2.1 D-alanine-D-lactate ligase
-
 Raoultella planticola
6.1.2.1 D-alanine-D-lactate ligase
-
 Pseudomonas plecoglossicida
6.1.2.1 D-alanine-D-lactate ligase
-
 Pseudomonas koreensis
6.1.2.1 VanA
-
 Pseudomonas fluorescens
6.1.2.1 VanA
-
 Enterococcus faecalis
6.1.2.1 VanA
-
 Enterococcus faecium
6.1.2.1 VanA
-
 Comamonas testosteroni
6.1.2.1 VanA
-
 Raoultella planticola
6.1.2.1 VanA
-
 Pseudomonas plecoglossicida
6.1.2.1 VanA
-
 Pseudomonas koreensis

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.2.1 ATP
-
 Pseudomonas fluorescens
6.1.2.1 ATP
-
 Enterococcus faecalis
6.1.2.1 ATP
-
 Enterococcus faecium
6.1.2.1 ATP
-
 Comamonas testosteroni
6.1.2.1 ATP
-
 Raoultella planticola
6.1.2.1 ATP
-
 Pseudomonas plecoglossicida
6.1.2.1 ATP
-
 Pseudomonas koreensis