BRENDA - Enzyme Database show

Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes

Moroni, P.; Buronfosse, T.; Longin-Sauvageon, C.; Delatour, P.; Benoit, E.; Drug Metab. Dispos. 23, 160-165 (1995)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.73
clotrimazole
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.14.14.73
microsome
-
Rattus norvegicus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.14.73
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.73
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.73
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
744768
Rattus norvegicus
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.14.14.73
cytochrome P450
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.14.14.73
cytochrome P450
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.73
clotrimazole
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.14.14.73
microsome
-
Rattus norvegicus
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.73
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.73
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
744768
Rattus norvegicus
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.14.14.73
physiological function
two main enzymatic systems, cytochrome P450s and flavin-containing monooxygenase, are responsible for the sulfoxidation of albendazole. P450 inhibitors inhibit the production of (-)-albendazole S-oxide more than the production of (+)-albendazole S-oxide
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.14.14.73
physiological function
two main enzymatic systems, cytochrome P450s and flavin-containing monooxygenase, are responsible for the sulfoxidation of albendazole. P450 inhibitors inhibit the production of (-)-albendazole S-oxide more than the production of (+)-albendazole S-oxide
Rattus norvegicus