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Literature summary extracted from

  • Lee, C.; Neul, D.; Clouser-Roche, A.; Dalvie, D.; Wester, M.; Jiang, Y.; Jones III, J.; Freiwald, S.; Zientek, M.; Totah, R.
    Identification of novel substrates for human cytochrome P450 2J2 (2010), Drug Metab. Dispos., 38, 347-356 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.73 medicine enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol with in vitro intrinsic clearance values ranging from 0.06 to 3.98 microl/min/pmol CYP2J2. Whereas isoform CYP3A4 commonly metabolizes compounds at multiple sites, CYP2J2 metabolism is more restrictive and limited, in general, to a single site for large compounds Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.14.14.73 homology modeling of structure Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.73 Homo sapiens P51589
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.73 commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.73 albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.73 amiodarone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.73 astemizole + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.73 cyclosporin + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.73 danazol + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.73 mesoridazine + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.73 additional information enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol. The substrates vary in size and overall topology from relatively rigid structures (amiodarone) to larger complex structures (cyclosporine). CYP2J2 metabolism is more restrictive than that of YP3A4 and limited, in general, to a single site for large compounds Homo sapiens ?
-
?
1.14.14.73 thioridazine + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.73 cytochrome P450 2J2
-
Homo sapiens