EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.14.73 | medicine | enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol with in vitro intrinsic clearance values ranging from 0.06 to 3.98 microl/min/pmol CYP2J2. Whereas isoform CYP3A4 commonly metabolizes compounds at multiple sites, CYP2J2 metabolism is more restrictive and limited, in general, to a single site for large compounds | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.14.14.73 | homology modeling of structure | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.73 | Homo sapiens | P51589 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.73 | commercial preparation | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.73 | albendazole + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.73 | amiodarone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.73 | astemizole + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.73 | cyclosporin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.73 | danazol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.73 | mesoridazine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.73 | additional information | enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol. The substrates vary in size and overall topology from relatively rigid structures (amiodarone) to larger complex structures (cyclosporine). CYP2J2 metabolism is more restrictive than that of YP3A4 and limited, in general, to a single site for large compounds | Homo sapiens | ? | - |
? | |
1.14.14.73 | thioridazine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.73 | cytochrome P450 2J2 | - |
Homo sapiens |