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Literature summary extracted from

  • de Araujo, M.E.M.B.; Franco, Y.E.M.; Alberto, T.G.; Messias, M.C.F.; Leme, C.W.; Sawaya, A.C.H.F.; Carvalho, P.O.
    Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically (2017), J. Enzyme Inhib. Med. Chem., 32, 978-985 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol 90% inhibition at 0.045 mM Bos taurus
1.17.3.2 naringin about 15% inhibition at 0.045 mM Bos taurus
1.17.3.2 naringin decanoate about 24% inhibition at 0.045 mM Bos taurus
1.17.3.2 naringin hexanoate about 15% inhibition at 0.045 mM Bos taurus
1.17.3.2 naringin laurate below 10% inhibition at 0.045 mM Bos taurus
1.17.3.2 naringin octanoate about 26% inhibition at 0.045 mM Bos taurus
1.17.3.2 naringin oleate below 10% inhibition at 0.045 mM Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.3.2 additional information
-
 additional information Michaelis-Menten and Lineweaver-Burk kinetics Bos taurus
1.17.3.2 0.017
-
 xanthine pH 7.4, 37°C Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 hypoxanthine + NAD+ + H2O Bos taurus
-
 xanthine + NADH + H+
-
 ?
1.17.3.2 xanthine + H2O + O2 Bos taurus
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus P80457
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 commercial preparation
-
 Bos taurus
-
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 hypoxanthine + NAD+ + H2O
-
 Bos taurus xanthine + NADH + H+
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.3.2 NAD+
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.3.2 additional information
-
 additional information inhibition kinetics Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 0.01467
-
 pH 7.4, 37°C Bos taurus allopurinol
1.17.3.2 0.11035
-
 pH 7.4, 37°C Bos taurus naringin octanoate
1.17.3.2 0.11751
-
 pH 7.4, 37°C Bos taurus naringin decanoate