Any feedback?
Literature summary extracted from
- Natural and engineered production of taxadiene with taxadiene synthase (2015), Biotechnol. Bioeng., 112, 229-235 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.2.3.17 | synthesis | taxadiene synthase ist he rate-limiting enzyme in the biosynthesis of the anticancer compound paclitaxel | Taxus brevifolia |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.3.17 | expressed in Escherichia coli | Taxus brevifolia |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.17 | 0.003 | - |
geranylgeranyl diphosphate | pH and temperature not specified in the publication | Taxus brevifolia |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.17 | Mg2+ | dependent on | Taxus brevifolia | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.17 | geranylgeranyl diphosphate | Taxus brevifolia | - |
taxa-4,11-diene + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.3.17 | Taxus brevifolia | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.17 | geranylgeranyl diphosphate | - |
Taxus brevifolia | taxa-4,11-diene + diphosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.3.17 | ? | x * 100000, SDS-PAGE | Taxus brevifolia |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.3.17 | TXS | - |
Taxus brevifolia |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.17 | 0.0106 | - |
geranylgeranyl diphosphate | pH and temperature not specified in the publication | Taxus brevifolia | |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.17 | 3.5 | - |
geranylgeranyl diphosphate | pH and temperature not specified in the publication | Taxus brevifolia | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
