Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hoffman, G.E.; Koban, M.
    Hypothalamic L-histidine decarboxylase is up-regulated during chronic REM sleep deprivation of rats (2016), PLoS ONE, 11, e0152252 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Rattus norvegicus
-
 histamine + CO2
-
 ?
4.1.1.22 L-histidine Rattus norvegicus Sprague-Dawley
-
 histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Rattus norvegicus P16453
-
-
4.1.1.22 Rattus norvegicus Sprague-Dawley P16453
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 brain
-
 Rattus norvegicus
-
4.1.1.22 hypothalamus
-
 Rattus norvegicus
-
4.1.1.22 additional information immunolocalization of histamine, with rabbit anti-L-histidine decarboxylase (HDC) antiserum, within the tuberomammillary nucleus is validated using carbodiimide. Rapid eye movement sleep deprivation (REM-SD) increases immunoreactive L-histidine decarboxylase by day 5, and it remains elevated in both dorsal and ventral aspects of the tuberomammillary complex Rattus norvegicus
-
4.1.1.22 neuron neurons of the tuberomammillary nucleus of the posterior hypothalamus Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Rattus norvegicus histamine + CO2
-
 ?
4.1.1.22 L-histidine
-
 Rattus norvegicus Sprague-Dawley histamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Rattus norvegicus
4.1.1.22 L-Histidine decarboxylase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
4.1.1.22 Rattus norvegicus rapid eye movement sleep deprivation (REM-SD) increases immunoreactive L-histidine decarboxylase by day 5, and it remains elevated in both dorsal and ventral aspects of the tuberomammillary complex up

General Information

EC Number General Information Comment Organism
4.1.1.22 metabolism L-histidine decarboxylase is the rate-limiting enzyme for histamine biosynthesis Rattus norvegicus
4.1.1.22 physiological function L-histidine decarboxylase (HDC) is the enzyme responsible for histamine biosynthesis in tuberomammillary nucleus (TMN) neurons of the posterior hypothalamus, the rate-limiting enzyme for histamine biosynthesis might be upregulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Upregulation of L-HDC within the tuberomammillary complex during chronic REM-SD is responsible for maintaining wakefulness. Chronic loss of sleep causes the rat to manifest a number of pathologies or syndromes Rattus norvegicus